Additional Supporting Information may be found in the online version of this article.

stem1606-sup-0001-suppfig01.tiff2702KSupplemental Figure 1. Proliferative defect and up-regulation of p16INK4a in Lin-cKit+ MozHAT-/- hematopoietic progenitors.
stem1606-sup-0002-suppfig02.tiff2702KSupplemental Figure 2. Expansion rate of MozHAT-/- neurospheres significantly increases in the absence of INK4a.
stem1606-sup-0003-suppfig03.tiff2702KSupplemental Figure 3. MozHAT-/- mouse embryonic fibroblasts display a marked proliferation defect and undergo early entrance into replicative senescence.

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