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Tissue-Specific Stem Cells
Article first published online: 9 JUL 2009
Copyright © 2009 AlphaMed Press
Volume 27, Issue 11, pages 2734–2743, November 2009
How to Cite
Mias, C., Lairez, O., Trouche, E., Roncalli, J., Calise, D., Seguelas, M.-H., Ordener, C., Piercecchi-Marti, M.-D., Auge, N., Salvayre, A. N., Bourin, P., Parini, A. and Cussac, D. (2009), Mesenchymal Stem Cells Promote Matrix Metalloproteinase Secretion by Cardiac Fibroblasts and Reduce Cardiac Ventricular Fibrosis After Myocardial Infarction. STEM CELLS, 27: 2734–2743. doi: 10.1002/stem.169
Author contributions: C.M.: Conception and design, collection and/or assembly of data, data analysis and interpretation, manuscript writing; O.L.: Collection and/or assembly of data, data analysis and interpretation; E.T.: Collection and/or assembly of data, data analysis and interpretation; J.R.: Conception and design; D. Calise: Collection and/or assembly of data, data analysis and interpretation; M.-H.S.: Collection and/or assembly of data; C.O.: Collection and/or assembly of data; M.-D.P.-M.: Collection and/or assembly of data; N.A.: Collection and/or assembly of data; A.N.S.: Collection and/or assembly of data; P.B.: Conception and design, provision of study material or patients; A.P.: Conception and design, data analysis and interpretation, manuscript writing, final approval of manuscript, financial support; D. Cussac: Conception and design, data analysis and interpretation, manuscript writing, final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLS EXPRESS 2009.
- Issue published online: 6 NOV 2009
- Article first published online: 9 JUL 2009
- Accepted manuscript online: 9 JUL 2009 12:00AM EST
- Manuscript Accepted: 28 JUN 2009
- Manuscript Received: 9 MAR 2009
- National Research Agency (ANR) (Grant under program Physiopathologie des Maladies Humaines, project SYNMESCARI)
- Région Midi-Pyrénées
- Fondation pour la Recherche Médicale (FRM)
Additional supporting information available online.
|STEM_169_sm_SuppFig1.tif||1274K||Supplemental data 1. Cardiac morphology after myocardial infarction Supplemental data 1A shows the kinetic of the protocol. Supplemental data 1B shows cardiac morphology (Hematoxylin/Eosin staining, panels a and c) and tissue fibrosis (Red Sirius staining, panels b and d) of the left ventricle 15 days after permanent ligation of the interventricular artery as compared to sham-operated rats (magnification x 200) (n≥5 animals per group).|
|STEM_169_sm_SuppFig2.tif||1759K||Supplemental data 2. MSCs survival and cardiac angiogenesis after graft. Supplemental data 2A shows QD-labeled cells (panel a), the number of apoptotic (panel b) or proliferative MSCs (panel c). Supplemental data 2B shows quantification of angiogenesis in the scar area of rats injected with untreated or melatonin-treated MSCs (n≥5 animals per group).|
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