Telephone: 713-794-5644; Fax: 713-794-4747
Translational and Clinical Research
Version of Record online: 30 JUL 2009
Copyright © 2009 AlphaMed Press
Volume 27, Issue 10, pages 2614–2623, October 2009
How to Cite
Kidd, S., Spaeth, E., Dembinski, J. L., Dietrich, M., Watson, K., Klopp, A., Battula, V. L., Weil, M., Andreeff, M. and Marini, F. C. (2009), Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging. STEM CELLS, 27: 2614–2623. doi: 10.1002/stem.187
Author contributions: S.K.: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing; E.S.: conception and design, data analysis and interpretation, manuscript writing; J.L.D.: conception and design, collection and assembly of data, data analysis and interpretation; M.D.: collection and assembly of data, provision of study material; K.W.: collection and assembly of data; A.K.: collection and assembly of data; L.B.: collection and assembly of data; M.W.: provision of study material; M.A.: conception and design, financial support; F.C.M.: conception and design, data analysis and interpretation, financial support, final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLS EXPRESS July 30, 2009.
- Issue online: 13 OCT 2009
- Version of Record online: 30 JUL 2009
- Accepted manuscript online: 30 JUL 2009 12:00AM EST
- Manuscript Accepted: 22 JUL 2009
- Manuscript Received: 14 JAN 2009
- National Cancer Institute. Grant Numbers: CA-109451, Ca-116199, CA-55164, CA-16672, CA-49639
- Paul and Mary Haas Chair in Genetics
- Rosalie B Hite Foundation
- Susan G Komen Breast Cancer Foundation
- Army Department of Defense. Grant Number: BC083397
- 1Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65: 3307–3318., , et al.
- 2Mesenchymal stem cells: Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004; 96: 1593–1603., , et al.
- 3Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 2008; 180: 2581–2587., , et al.
- 4Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine 2004; 29: 1971–1979., , .
- 5Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 2005; 1035: 73–85., , et al.
- 6Inflammation and tumor microenvironments: Defining the migratory itinerary of mesenchymal stem cells. Gene Ther 2008; 15: 730–738., , et al.
- 7Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104: 2224–2234., , .
- 8Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem 2006; 281: 15554–15563., , et al.
- 9Distribution of intravenously grafted bone marrow mesenchymal stem cells in the viscera tissues of rats before, after cerebral ischemia. J Clin Rehab Tissue Eng Res 2007; 11: 10160–10164., , et al.
- 10Adult mesenchymal stromal stem cells for therapeutic applications. Minim Invasive Ther Allied Technol 2008; 17: 79–90., .
- 11Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res 2007; 67: 11687–11695., , et al.
- 12Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model. Br J Radiol 2007; 80: S49–S55., , et al.
- 13Consensus conference on European preparedness for haematological and other medical management of mass radiation accidents. Ann Hematol 2006; 85: 671–679., , et al.
- 14Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315: 1650–1659..
- 15Bone marrow-derived stem cells in wound healing: A review. Wound Repair Regen 2007; 15( suppl 1): S18–S26., , et al.
- 16Xenotransplant cardiac chimera: Immune tolerance of adult stem cells. Ann Thorac Surg 2002; 74: 19–24; discussion 24., , et al.
- 17Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701–705., , et al.
- 18Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001; 107: 1395–1402., , et al.
- 19Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat Embryol (Berl) 1999; 199: 391–396., , et al.
- 20Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5: 309–313., , et al.
- 21Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A 2002; 99: 2199–2204., , et al.
- 22Management of acute graft-versus-host disease. Br J Haematol 2007; 137: 87–98..
- 23The (in) auspicious role of mesenchymal stromal cells in cancer: Be it friend or foe. Cytotherapy 2008; 10: 657–667., , et al.
- 24Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002; 62: 3603–3608., , et al.
- 25Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice. Transplantation 2004; 78: 503–508., , et al.
- 26Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci U S A 1995; 92: 4857–4861., , et al.
- 27Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli. Proc Natl Acad Sci U S A 1985; 82: 7870–7873., , et al.
- 28Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia 2000; 2: 41–52., , et al.
- 29Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem Photobiol 1997; 66: 523–531., , et al.
- 30Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 2002; 4: 235–260., .
- 31Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A 1999; 96: 12044–12049., , et al.
- 32Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia 1999; 1: 303–310., , et al.
- 33Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter. Int Immunol 2007; 19: 1165–1173., , et al.
- 34Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 2003; 102: 3478–3482., , et al.
- 35Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A 2004; 101: 221–226., , et al.
- 36In vivo bioluminescence imaging of cord blood derived mesenchymal stem cell transplantation into rat myocardium. Ann Nucl Med 2006; 20: 165–170., , et al.
- 37Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation 2008; 118( 14 suppl): S121–S129., , et al.
- 38Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation 2009; 87: 642–652., , et al.
- 39Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury. Am J Physiol Renal Physiol 2008; 295: F315–F321., , et al.
- 40Imaging of mesenchymal stem cell transplant by bioluminescence and PET. J Nucl Med 2007; 48: 2011–2020., , et al.
- 41Real-time in vivo monitoring of viable stem cells implanted on biocompatible scaffolds. Eur J Nucl Med Mol Imaging 2008; 35: 1887–1898., , et al.
- 42The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer Res 2007; 67: 4210–4218., , et al.
- 43Comparison of the efficiency of transduction of leukemic cells by fiber-modified adenoviruses. Hum Gene Ther 2004; 15: 1229–1242., , et al.
- 44Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315–317., , et al.
- 45Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer. Proc Natl Acad Sci U S A 2008; 105: 14342–14346., , et al.
- 46Pulmonary passage is a major obstacle for intravenous stem cell delivery: The pulmonary first-pass effect. Stem Cells Dev 2009; 18: 683–692., , et al.
- 47Cell delivery mechanisms for tissue repair. Cell Stem Cell 2008; 2: 205–213., .
- 48Prospects for stem cell-based therapy. Cell 2008; 132: 544–548., .
- 49Improved autograft survival of mesenchymal stromal cells by plasminogen activator inhibitor 1 inhibition. Stem Cells 2009; 27: 467–477., , et al.
- 50Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One 2009; 4: e4992., , et al.
- 51Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells. Cell Transplant 2006; 15: 75–82., , et al.
- 52Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin Cancer Res 2005; 11: 7749–7756., , et al.
- 53In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. Radiology 2004; 233: 781–789., , et al.
- 54In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging. Laboratory investigation. J Neurosurg 2008; 108: 320–329., , et al.
- 55Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. Circulation 2007; 116( 11 suppl): I38–I45., , et al.