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Tissue-Specific Stem Cells
Version of Record online: 12 AUG 2009
Copyright © 2009 AlphaMed Press
Volume 27, Issue 10, pages 2571–2579, October 2009
How to Cite
May, R., Sureban, S. M., Hoang, N., Riehl, T. E., Lightfoot, S. A., Ramanujam, R., Wyche, J. H., Anant, S. and Houchen, C. W. (2009), Doublecortin and CaM Kinase-like-1 and Leucine-Rich-Repeat-Containing G-Protein-Coupled Receptor Mark Quiescent and Cycling Intestinal Stem Cells, Respectively. STEM CELLS, 27: 2571–2579. doi: 10.1002/stem.193
Author contributions: R.M., S.M.S.: conception and design, collection and assembly of data, data analysis and integration, manuscript writing, and final approval of the manuscript; T.E.R.: manuscript writing and final approval of the manuscript; S.A.L., R.R., J.W.H.: data analysis and integration and final approval of the manuscript; S.A.: conception and design, data analysis, and integration and final approval of the manuscript; C.W.H.: conception and design, financial support, collection and assembly of data, data analysis and integration, manuscript writing, and final approval of the manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLS EXPRESS August 12, 2009.
- Issue online: 13 OCT 2009
- Version of Record online: 12 AUG 2009
- Accepted manuscript online: 12 AUG 2009 12:00AM EST
- Manuscript Accepted: 12 AUG 2009
- Manuscript Received: 9 MAR 2009
- National Institute of Health Grants. Grant Numbers: DK-065887, DK-002822
- Veterans Administration Merit award
- 1Differentiation and self-renewal in the mouse gastrointestinal epithelium. Curr Opin Cell Biol 1994; 6: 795–803., .
- 2Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anatomy 1974; 141: 537–561., .
- 3Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium. J Cell Biol 1992; 119: 27–44., , et al.
- 4Cell migration pathway in the intestinal epithelium: An in situ marker system using mouse aggregation chimeras. Cell 1985; 40: 425–429., , .
- 5Stem-cell organization in mouse small intestine. Proc Biol Sci 1990; 241: 13–18., .
- 6A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy. J Theor Biol 1987; 127: 381–391., .
- 7Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the Crypt. Development 1990; 110: 1001–1020., .
- 8Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation. J Cell Biol 1992; 117: 825–839., , et al.
- 9The stem-cell zone of the small intestinal epithelium. IV. Effects of resecting 30% of the small intestine. Am J Anatomy 1981; 160: 93–103., .
- 10Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am J Anatomy 1974; 141: 461–479., .
- 11Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 1999; 116: 7–14., .
- 12In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci USA 1999; 96: 3120–3125., , et al.
- 13Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1990; 61: 1329–1337., , .
- 14Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425: 836–841., , et al.
- 15Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002; 115: 2381–2388., , .
- 16The intestinal epithelial stem cell. Bioessays 2002; 24: 91–98., , .
- 17Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003–1007., , et al.
- 18DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J Neurosci 2000; 20: 9152–9161., , et al.
- 19Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 2008; 26: 630–637., , et al.
- 20Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology 2008; 23: 350–359., .
- 21Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts. Am J Physiol Cell Physiol 2009; 296: C296–305., , et al.
- 22Colonic crypt organization and tumorigenesis. Nature Rev 2008; 8: 415–424., .
- 23Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J Biol Chem 2006; 281: 11292–11300., , et al.
- 24Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. Proc Natl Acad Sci USA 2008; 105: 4358–4363., , et al.
- 25Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum. Gastroenterology 2005; 129: 1567–1580., , et al.
- 26Progress on isolation and short-term ex-vivo culture of highly purified non-apoptotic human intestinal epithelial cells (IEC). Eur J Cell Biol 2003; 82: 262–270., , et al.
- 27Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. ScientificWorldJournal 2008; 8: 1168–1176., , .
- 28Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. Cancer Biol Ther 2006; 5: 419–426., , et al.
- 29The intestinal epithelial stem cell: The mucosal governor. Int J Exp Pathol 1997; 78: 219–243., , .
- 30Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development 2003; 130: 2793–2808., , et al.
- 31The doubling time of regenerating clonogenic cells in the crypts of the irradiated mouse small intestine. Int J Radiat Biol 1988; 54: 1041–1051., , .
- 32DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). Genomics 1999; 56: 121–126., .
- 33The DCX-domain tandems of doublecortin and doublecortin-like kinase. Nature Struct Biol 2003; 10: 324–333., , et al.
- 34Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a microRNA-dependent mechanism. Gastroenterology. 2009; 137: 649–659., , et al.
- 35In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003; 17: 1253–1270..
- 36The human keratins: Biology and pathology. Histochem Cell Biol 2008; 129: 705–733., , .
- 37Antibody markers of basal cells in complex epithelia. J Cell Sci 1990; 97( Pt 1): 39–50., , et al.
- 38Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo. Gastroenterology 2008; 134: 1448–1458. e1442., , et al.
- 39Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 2003; 71: 28–41..
- 40Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 2001; 294: 2155–2158., , et al.
- 41Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev 2005; 19: 2412–2417., , et al.
- 42Use of fetal intestinal isografts from normal and transgenic mice to study the programming of positional information along the duodenal-to-colonic axis. J Biol Chem 1992; 267: 15122–15133., , et al.
- 43The mouse ileal lipid-binding protein gene: a model for studying axial patterning during gut morphogenesis. J Cell Biol 1994; 126: 1547–1564., , .
- 44Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 2008; 40: 915–920., .