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References

  • 1
    Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154156.
  • 2
    Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A 1981; 78: 76347638.
  • 3
    Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 11451147.
  • 4
    Reubinoff BE, Pera MF, Fong CY et al. Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro. Nat Biotechnol 2000; 18: 399404.
  • 5
    Wang Z, Jaenisch R. At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation. Dev Biol 2004; 275: 192201.
  • 6
    Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: The paradigmatic tissue-specific stem cell. Am J Pathol 2006; 169: 338346.
  • 7
    Rathjen PD, Lake J, Whyatt LM et al. Properties and uses of embryonic stem cells: Prospects for application to human biology and gene therapy. Reprod Fertil Dev 1998; 10: 3147.
  • 8
    Odorico JS, Kaufman DS, Thomson JA. Multilineage differentiation from human embryonic stem cell lines. Stem Cells 2001; 19: 193204.
  • 9
    Levine AJ, Brivanlou AH. Proposal of a model of mammalian neural induction. Dev Biol 2007; 308: 247256.
  • 10
    Winnier G, Blessing M, Labosky PA et al. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995; 9: 21052116.
  • 11
    Liu P, Wakamiya M, Shea MJ et al. Requirement for Wnt3 in vertebrate axis formation. Nat Genet 1999; 22: 361365.
  • 12
    Sun X, Meyers EN, Lewandoski M et al. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 1999; 13: 18341846.
  • 13
    Tam PP, Loebel DA. Gene function in mouse embryogenesis: Get set for gastrulation. Nat Rev Genet 2007; 8: 368381.
  • 14
    Ciruna B, Rossant J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell 2001; 1: 3749.
  • 15
    Tada S, Era T, Furusawa C et al. Characterization of mesendoderm: A diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 2005; 132: 43634374.
  • 16
    Kopan R, Ilagan MX. Gamma-secretase: Proteasome of the membrane? Nat Rev Mol Cell Biol 2004; 5: 499504.
  • 17
    Lowell S, Benchoua A, Heavey B et al. Notch promotes neural lineage entry by pluripotent embryonic stem cells. Plos Biol 2006; 4: e121.
  • 18
    Nemir M, Croquelois A, Pedrazzini T et al. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res 2006; 98: 14711478.
  • 19
    Burdsal CA, Damsky CH, Pedersen RA. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development 1993; 118: 829844.
  • 20
    Marambaud P, Shioi J, Serban G et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 2002; 21: 19481956.
  • 21
    Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: Cell fate control and signal integration in development. Science 1999; 284: 770776.
  • 22
    Micchelli CA, Esler WP, Kimberly WT et al. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J 2003; 17: 7981.
  • 23
    Tian G, Ghanekar SV, Aharony D et al. The mechanism of gamma-secretase: Multiple inhibitor binding sites for transition state analogs and small molecule inhibitors. J Biol Chem 2003; 278: 2896828975.
  • 24
    Doetschman TC, Eistetter H, Katz M et al. The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 1985; 87: 2745.
  • 25
    Ying QL, Nichols J, Chambers I et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003; 115: 281292.
  • 26
    Ng ES, Azzola L, Sourris K et al. The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development 2005; 132: 873884.
  • 27
    Rathjen J, Rathjen PD. Lineage specific differentiation of mouse ES cells: Formation and differentiation of early primitive ectoderm-like (EPL) cells. Methods Enzymol 2003; 365: 325.
  • 28
    Rathjen J, Lake JA, Bettess MD et al. Formation of a primitive ectoderm-like cell population, EPL Cells, from ES cells in response to biologically derived factors. J Cell Sci 1999; 112( Pt 5): 601612.
  • 29
    Rathjen J, Haines BP, Hudson KM et al. Directed differentiation of pluripotent cells to neural lineages: Homogeneous formation and differentiation of a neurectoderm population. Development 2002; 129: 26492661.
  • 30
    Hughes JN, Washington JM, Zheng Z et al. Manipulation of cell:cell contacts and mesoderm suppressing activity direct lineage choice from pluripotent primitive ectoderm-like cells in culture. PLoS One 2009; 4( 5): e5579.
  • 31
    Simon P. Q-Gene: Processing quantitative real-time RT-PCR data. Bioinformatics 2003; 19: 14391440.
  • 32
    Muller PY, Janovjak H, Miserez AR et al. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 2002; 32: 13721374, 1376, 1378–1379.
  • 33
    Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365386.
  • 34
    Kavanagh SJ, Schulz TC, Davey P et al. A family of RS domain proteins with novel subcellular localization and trafficking. Nucleic Acids Res 2005; 33: 13091322.
  • 35
    Rathjen J, Washington JM, Bettess MD et al. Identification of a biological activity that supports maintenance and proliferation of pluripotent cells from the primitive ectoderm of the mouse. Biol Reprod 2003; 69: 18631871.
  • 36
    Robertson SM, Kennedy M, Shannon JM et al. A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1. Development 2000; 127: 24472459.
  • 37
    Shen MM, Leder P. Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc Natl Acad Sci U S A 1992; 89: 82408244.
  • 38
    Hayashi K, Lopes SM, Tang F et al. Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell 2008; 3: 391401.
  • 39
    Lake J, Rathjen J, Remiszewski J et al. Reversible programming of pluripotent cell differentiation. J Cell Sci 2000; 113( Pt 3): 555566.
  • 40
    Hughes JN, Washington JM, Zheng Z et al. Manipulation of cell:cell contacts and mesoderm suppressing activity direct lineage choice from pluripotent primitive ectoderm-like cells in culture. Plos One 2009; 4: e5579.
  • 41
    Hart AH, Hartley L, Sourris K et al. Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development 2002; 129: 35973608.
  • 42
    Johansson BM, Wiles MV. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 1995; 15: 141151.
  • 43
    Vallier L, Mendjan S, Brown S et al. Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 2009; 136: 13391349.
  • 44
    Ware CB, Wang L, Mecham BH et al. Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell 2009; 4: 359369.
  • 45
    Davis RP, Ng ES, Costa M et al. Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood 2008; 111: 18761884.
  • 46
    Adewumi O, Aflatoonian B, Ahrlund-Richter L et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol 2007; 25: 803816.
  • 47
    Aberdam E, Barak E, Rouleau M et al. A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells 2008; 26: 440444.
  • 48
    Troy TC, Turksen K. Commitment of embryonic stem cells to an epidermal cell fate and differentiation in vitro. Dev Dyn 2005; 232: 293300.
  • 49
    Wu S, Rhee KJ, Zhang M et al. Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage. J Cell Sci 2007; 120: 19441952.
  • 50
    Zohn IE, Li Y, Skolnik EY et al. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell 2006; 125: 957969.
  • 51
    Tam PP, Behringer RR. Mouse gastrulation: The formation of a mammalian body plan. Mech Dev 1997; 68: 325.
  • 52
    Mohamed OA, Clarke HJ, Dufort D. Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo. Dev Dyn 2004; 231: 416424.
  • 53
    Lindsley RC, Gill JG, Kyba M et al. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development 2006; 133: 37873796.
  • 54
    Donoviel DB, Hadjantonakis AK, Ikeda M et al. Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev 1999; 13: 28012810.
  • 55
    Baki L, Marambaud P, Efthimiopoulos S et al. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc Natl Acad Sci U S A 2001; 98: 23812386.
  • 56
    Tesar PJ, Chenoweth JG, Brook FA et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007; 448: 196199.
  • 57
    Brons IG, Smithers LE, Trotter MW et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007; 448: 191195.
  • 58
    Pera MF, Andrade J, Houssami S et al. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci 2004; 117: 12691280.
  • 59
    Xu RH, Chen X, Li DS et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol 2002; 20: 12611264.
  • 60
    Zhang P, Li J, Tan Z et al. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood 2008; 111: 19331941.
  • 61
    Chambers SM, Fasano CA, Papapetrou EP et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 2009; 27: 275280.
  • 62
    Hemmati-Brivanlou A, Melton D. Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell 1997; 88: 1317.
  • 63
    Wilson PA, Hemmati-Brivanlou A. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 1995; 376: 331333.
  • 64
    Davis S, Miura S, Hill C et al. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol 2004; 270: 4763.
  • 65
    Elefanty AG, Robb L, Birner R et al. Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells. Blood 1997; 90: 14351447.
  • 66
    Lin T, Chao C, Saito S et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005; 7: 165171.