Regenerative Medicine

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Challenges of Stem Cell Therapy for Spinal Cord Injury: Human Embryonic Stem Cells, Endogenous Neural Stem Cells, or Induced Pluripotent Stem Cells?†‡§

  1. Mohammad Ronaghi,
  2. Slaven Erceg,
  3. Victoria Moreno-Manzano,
  4. Miodrag Stojkovic¶,*

Article first published online: 10 NOV 2009

DOI: 10.1002/stem.253

Issue

STEM CELLS

STEM CELLS

Volume 28, Issue 1, pages 93–99, January 2010

Additional Information

How to Cite

Ronaghi, M., Erceg, S., Moreno-Manzano, V. and Stojkovic, M. (2010), Challenges of Stem Cell Therapy for Spinal Cord Injury: Human Embryonic Stem Cells, Endogenous Neural Stem Cells, or Induced Pluripotent Stem Cells?. STEM CELLS, 28: 93–99. doi: 10.1002/stem.253

Author Information

  1. Cellular Reprogramming Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain

  1. Telephone: +34 96 328 9680

*Avda Autopista del Saler 16, CIPF, 46012, Valencia, Spain

  1. †

    Author contributions: M.R., S.E., V.M.-M., and M.S. manuscript writing; M.S. final approval of the manuscript.

  2. ‡

    Disclosure of potential conflicts of interest is found at the end of this article.

  3. §

    First published online in STEM CELLS EXPRESS November 10, 2009; available online without subscription through the open access option.

Publication History

  1. Issue published online: 12 JAN 2010
  2. Article first published online: 10 NOV 2009
  3. Accepted manuscript online: 10 NOV 2009 12:00AM EST
  4. Manuscript Accepted: 1 NOV 2009
  5. Manuscript Received: 8 JUL 2009

Funded by

  • Regenerative Medicine from the Regional Government Health Department (Generalitat Valenciana)
  • Instituto Carlos III belonging to the Spanish Ministry of Health and Consumer Affairs
  • Spanish Ministry of Science and Innovation. Grant Number: SAF2007-63193
  • La Marato. Grant Number: TV3 070330

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Keywords:

  • embryonic stem cells;
  • iPS cells;
  • stem cell therapy;
  • spinal cord

Abstract

Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber tracts that carry sensation and motor signals to and from the brain. The gray matter damage causes segmental losses of interneurons and motoneurons and restricts therapeutic options. Recent advances in stem cell biology, neural injury, and repair, and the progress toward development of neuroprotective and regenerative interventions are the basis for increased optimism. This review summarizes the pathophysiological mechanisms following SCI and compares human embryonic, adult neural, and the induced pluripotent stem cell-based therapeutic strategies for SCI. STEM CELLS 2010;28:93–99

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