Embryonic Stem Cells/Induced Pluripotent Stem Cells

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Human Embryonic Stem Cell Lines and Their Use in International Research†‡§

  1. Peter Löser1,¶,*,
  2. Jacqueline Schirm1,
  3. Anke Guhr1,
  4. Anna M. Wobus2,
  5. Andreas Kurtz3

Article first published online: 21 DEC 2009

DOI: 10.1002/stem.286

Issue

STEM CELLS

STEM CELLS

Volume 28, Issue 2, pages 240–246, February 2010

Additional Information

How to Cite

Löser, P., Schirm, J., Guhr, A., Wobus, A. M. and Kurtz, A. (2010), Human Embryonic Stem Cell Lines and Their Use in International Research. STEM CELLS, 28: 240–246. doi: 10.1002/stem.286

Author Information

  1. 1

    Robert Koch Institute, Berlin, Germany

  2. 2

    Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany

  3. 3

    Berlin Brandenburg Center for Regenerative Therapies and European Human Embryonic Stem Cell Registry (hESCreg), Charité, Berlin, Germany

  1. Telephone: +49-30-18754-3127; Fax: +49-30-18754-3206

*Robert Koch Institute, DGZ-Ring 1, D-13086 Berlin, Germany

  1. †

    Author contributions: P.L.: Conception and design, Collection and/or assembly of data, data analysis and interpretation, manuscript writing; J.S.: Collection and/or assembly of data, administrative support; A.G.: Collection and/or assembly of data, administrative support; A.M.W.: Conception and design, data analysis and interpretation, manuscript writing; A.K.: Conception and design, data analysis and interpretation, manuscript writing.

  2. ‡

    Disclosure of potential conflicts of interest is found at the end of this article.

  3. §

    First published online in STEM CELLSEXPRESS January 28, 2010.

Publication History

  1. Issue published online: 16 FEB 2010
  2. Article first published online: 21 DEC 2009
  3. Accepted manuscript online: 21 DEC 2009 12:00AM EST
  4. Manuscript Accepted: 11 DEC 2009
  5. Manuscript Received: 2 NOV 2009

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Keywords:

  • Embryonic stem cells;
  • Pluripotent stem cells;
  • hESC Lines;
  • hESC Research;
  • hESC Usage;
  • Human induced pluripotent stem cells;
  • hiPSCs

Abstract

Research in human pluripotent stem cells, including human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC), is one of the most dynamic research fields. Despite the high public attention, especially for hESC research, there is only scattered information on the number of hESC lines and the degree, dynamics, and diversification of their use on a global level. In this study we present data on the current number of publicly disclosed hESC lines, on the extent and impact of experimental work involving hESCs, and on the use of specific hESC lines in international research. The results are based on the evaluation of nearly 1,000 research papers published by the end of 2008, which describe experimental work on hESCs, and of a comprehensive database of published hESC lines. The average impact of hESC research papers is high at 7.422, with a predominance of research output by the United States. Of at least 1,071 original hESC lines derived up to November 2009 at 87 institutions in 24 countries, only a fraction is thoroughly characterized. Our data show the global predominance of a few hESC lines in research, but also reveal remarkable country-specific differences. Comparison of hESC and hiPSC application did not show a diminished role for hESC research, but rather revealed that, up to this time, both fields continue to expand, exist independently, and partially overlap. STEM CELLS 2010;28:240–246

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