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Tissue-Specific Stem Cells
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Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle†‡§
Article first published online: 10 MAY 2010
DOI: 10.1002/stem.442
Copyright © 2010 AlphaMed Press
Additional Information
How to Cite
Genander, M., Holmberg, J. and Frisén, J. (2010), Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle. STEM CELLS, 28: 1196–1205. doi: 10.1002/stem.442
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Author contributions: M.G.: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing; J.H.: collection and assembly of data, data analysis and interpretation; J.F.: conception and design, financial support, data analysis and interpretation, manuscript writing.
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First published online in STEM CELLSEXPRESS May 10, 2010.
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Disclosure of potential conflicts of interest is found at the end of this article.
Publication History
- Issue published online: 20 JUL 2010
- Article first published online: 10 MAY 2010
- Manuscript Accepted: 29 APR 2010
- Manuscript Received: 12 FEB 2010
Funded by
- Swedish Cancer Society
- Swedish Research Council
- Karolinska Institute
- Tobias Stiftelsen and Knut och Alice Wallenbergs Stiftelse
Keywords:
- Adult stem cells;
- Epidermis;
- Tissue-specific stem cells;
- Cellular proliferation
Abstract
Ephrins and their Eph tyrosine kinase receptors control many processes during embryonic development. They have more recently also been identified as important regulators of proliferation of stem/progenitor cells in the adult brain and intestine and have been implicated in tumorigenesis in a large number of tissues. We here describe the expression of a large number of ephrins and Eph receptors in the adult mouse skin. Disruption of the ephrin-Eph interaction in vivo with antagonists against the A or B class resulted in an approximate doubling of cell proliferation in the hair follicle and epidermis of adult mice. We conclude that ephrins are negative regulators of proliferation in the skin and that blocking the ephrin-Eph interaction may be an attractive strategy for regenerative therapies. STEM CELLS 2010;28:1196–1205