Tissue-Specific Stem Cells

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Concise Review: Multiple Niches for Hematopoietic Stem Cell Regulations†‡§

  1. Il-Hoan Oh1,2,¶,*,
  2. Kyung-Rim Kwon1,2

Article first published online: 1 JUN 2010

DOI: 10.1002/stem.453

Issue

STEM CELLS

STEM CELLS

Volume 28, Issue 7, pages 1243–1249, July 2010

Additional Information

How to Cite

Oh, I.-H. and Kwon, K.-R. (2010), Concise Review: Multiple Niches for Hematopoietic Stem Cell Regulations. STEM CELLS, 28: 1243–1249. doi: 10.1002/stem.453

Author Information

  1. 1

    The Catholic High-Performance Cell Therapy Center, Division of Regenerative Medicine, College of Medicine, Seoul

  2. 2

    The Catholic University of Korea, Korea

  1. Telephone: 82-2-2258-8268, Fax: 82-2-591-3994

*Catholic High-Performance Cell Therapy Center, The Catholic University of Korea, 505, Banpo-Dong, Seocho-Ku, Seoul, Korea 137-701

  1. †

    Author contributions: IHO: conception and design, manuscript writing, financial support, KRK: conception and design, collection and assembly of material.

  2. ‡

    First published online in STEM CELLSEXPRESS June 1, 2010; available online without subscription through the open access option.

  3. §

    Disclosure of potential conflicts of interest is found at the end of this article.

Publication History

  1. Issue published online: 20 JUL 2010
  2. Article first published online: 1 JUN 2010
  3. Manuscript Accepted: 10 MAY 2010
  4. Manuscript Received: 13 APR 2010

Funded by

  • Ministry of Health, Welfare and Family. Grant Number: 0405-DB01-0104-0006
  • Korea Science and Engineering Foundation (KOSEF). Grant Number: 2008-05981

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Keywords:

  • Stem cell niche;
  • Microenvironment;
  • Osteoblast;
  • Vascular niche

Abstract

Two types of stem cell niches in bone marrow (BM), endosteal osteoblastic, and vascular niches are involved in the microenvironmental regulation of hematopoietic stem cells (HSCs). Recently, redundant features of the two niches were identified, based on their common cellular origins or chemical mediators being produced in each niche. In contrast, studies have also revealed that HSCs are localized differentially in the niches with respect to their distinct functional status, and that the biological activity of each niche is differentially influenced by extrinsic conditions. An important question is, therefore, whether these two niches play distinct roles in regulating HSCs and whether they respond differentially to environmental stimuli/stress for “compartmentalized” niche organization in BM. In this review, recent discoveries related to the characteristics of each type of niche and their common or unique features are discussed, along with the possibility of multiniche regulation of HSCs in BM. STEM CELLS 2010;28:1243–1249

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