Telephone: +34-95-446-76-21; Fax: +34-95-446-16-64
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Article first published online: 27 JUL 2010
Copyright © 2010 AlphaMed Press
Volume 28, Issue 9, pages 1541–1549, September 2010
How to Cite
Erceg, S., Ronaghi, M., Oria, M., García Roselló, M., Aragó, M. A. P., Lopez, M. G., Radojevic, I., Moreno-Manzano, V., Rodríguez-Jiménez, F.-J., Shanker Bhattacharya, S., Cordoba, J. and Stojkovic, M. (2010), Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection. STEM CELLS, 28: 1541–1549. doi: 10.1002/stem.489
Author contributions: S.E.: conception and design, data analysis and interpretation, manuscript writing, final approval of manuscript, experiments; M.R.: experiments; M.O.: experiments, data analysis and interpretation; M.G.R.: experiments, surgery; M.A.P.A., M.G.L., I.R., V.M.-M., and F.J.R.-J.: experiments; S.S.B. and J.C.: data analysis and interpretation; M.S.: conception and design, data analysis and interpretation, manuscript writing, final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLS EXPRESS July 22, 2010.
- Issue published online: 27 JUL 2010
- Article first published online: 27 JUL 2010
- Manuscript Accepted: 15 JUL 2010
- Manuscript Received: 8 APR 2010
- Regional Government Health Department (Generalitat Valenciana)
- Instituto Carlos III belonging to the Spanish Ministry of Health and Consumer Affairs
- Spanish Ministry of Science and Innovation. Grant Number: SAF2007-63193
- La Marato. Grant Number: TV3 070,330
- Embryonic stem cells;
- Stem cell transplantation;
- Neural differentiation
Human embryonic stem cells (hESC) hold great promise for the treatment of patients with many neurodegenerative diseases particularly those arising from cell loss or neural dysfunction including spinal cord injury. This study evaluates the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult rats after complete spinal cord transection. OPC and/or MP were grafted into the site of injury in the acute phase. Based on Basso-Beattie-Bresnahan scores recovery of locomotor function was significantly enhanced in rats treated with OPC and/or MP when compared with control animals. When transplanted into the spinal cord immediately after complete transection, OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons showing in vivo electrophysiological activity. Taken together, these results indicate that OPC and MP derived from hESC could be a useful therapeutic strategy to repair injured spinal cord. STEM CELLS 2010; 28:1541–1549.