Article first published online: 24 FEB 2011
Copyright © 2010 AlphaMed Press
Volume 29, Issue 2, pages 169–178, February 2011
How to Cite
Wright, K. T., Masri, W. E., Osman, A., Chowdhury, J. and Johnson, W. E. B. (2011), Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications. STEM CELLS, 29: 169–178. doi: 10.1002/stem.570
Author contributions: K.T.W., W.E.M., and W.E.B.J.: conception and design and manuscript writing; W.E.B.J.: financial support; K.T.W.: provision of study material, collection and assembly of data and data analysis and interpretation; K.T.W., W.E.M., A.O., J.C., and W.E.B.J.: final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS November 23, 2010; available online without subscription through the open access option.
- Issue published online: 24 FEB 2011
- Article first published online: 24 FEB 2011
- Accepted manuscript online: 23 NOV 2010 12:03PM EST
- Manuscript Accepted: 10 NOV 2010
- Manuscript Received: 22 JUL 2010
- Adult human bone marrow;
- Spinal cord injury;
- Cell transplantation;
- Clinical translations and clinical trials
Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into central nervous system cells but focus on the neurotrophic, tissue sparing, and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date. STEM CELLS 2011;29:169–178