C. Khandanpour and C. Kosan contributed equally to this work.
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Translational and Clinical Research
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Growth Factor Independence 1 Protects Hematopoietic Stem Cells Against Apoptosis but Also Prevents the Development of a Myeloproliferative-Like Disease†‡§
Article first published online: 24 FEB 2011
DOI: 10.1002/stem.575
Copyright © 2010 AlphaMed Press
Additional Information
How to Cite
Khandanpour, C., Kosan, C., Gaudreau, M.-C., Dührsen, U., Hébert, J., Zeng, H. and Möröy, T. (2011), Growth Factor Independence 1 Protects Hematopoietic Stem Cells Against Apoptosis but Also Prevents the Development of a Myeloproliferative-Like Disease. STEM CELLS, 29: 376–385. doi: 10.1002/stem.575
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Author contributions: C. Khandanpour and C. Kosan: design of experiments, collection, interpretation and analysis of data, manuscript writing; M.-C.G. and U.D.: collection, interpretation, and analysis of data; H.Z.: design of experiments, interpretation, and analysis of data; J.H.: karyotype analysis; T.M.: conception of work, design of experiments, interpretation and analysis of data, writing of manuscript, financial support, and funding.
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Disclosure of potential conflicts of interest is found at the end of this article.
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First published online in STEM CELLSEXPRESS December 9, 2010.
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C. Khandanpour and C. Kosan contributed equally to this work.
Telephone: +86-10-84322621. Fax: +86-10-84322606
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Telephone: 514-987-5501; Fax: 514-987-5679
Publication History
- Issue published online: 24 FEB 2011
- Article first published online: 24 FEB 2011
- Accepted manuscript online: 9 DEC 2010 08:27AM EST
- Manuscript Accepted: 16 NOV 2010
- Manuscript Received: 2 JUL 2010
Funded by
- Deutsche Forschungsgemeinschaft, DFG, and the Cancer Research Society, Canada
- Cole Foundation
- Cancer Research Network of Fonds de la Recherche en Santé du Québec
- Ministry of Human Resources and Social Security, China
- Canada Research Chair (Tier one) and funds from the IRCM
References
- 1, , . The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol 1995; 11: 35–71.
- 2, , et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 2001; 15: 659–669.
- 3, , et al. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 2006; 107: 358–366.
- 4, . Hematopoiesis: An evolving paradigm for stem cell biology. Cell 2008; 132: 631–644.
- 5, , . Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev 2009; 19: 461–468.
- 6, , et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008; 135: 1118–1129.
- 7, , et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 2004; 431: 1002–1007.
- 8. The zinc finger transcription factor growth factor independence 1 (Gfi1). Int J Biochem Cell Biol 2005; 37: 541–546.
- 9, , et al. A recurrent network involving the transcription factors PU. 1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 2009; 31: 576–586.
- 10, , et al. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 2004; 23: 4116–4125.
- 11, , et al. Repression of Id2 expression by Gfi-1 is required for B cell and myeloid development. Blood 2010;116:1060–1069.
- 12, , et al. The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. Blood 2010; 115: 3970–3979.
- 13, , . Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood 2009; 113: 4720–4728.
- 14, , et al. p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell 2009; 4: 37–48.
- 15, , et al. Gfi1 negatively regulates T(h) 17 differentiation by inhibiting RORgammat activity. Int Immunol 2009; 21: 881–889.
- 16, , et al. Gfi1 integrates progenitor versus granulocytic transcriptional programming. Blood 2009; 113: 5466–5475.
- 17, , et al. Transcription factor Gfi1 restricts B cell-mediated autoimmunity. J Immunol 2008; 181: 6222– 6229.
- 18, , et al. Gfi1-cells and circuits: Unraveling transcriptional networks of development and disease. Curr Opin Hematol 2010; 17: 300–307.
- 19, , et al. The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts. Eur J Immunol 2008; 38: 3004– 3014.
- 20, , et al. Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol 2007; 37: 3551–3563.
- 21, , . Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing. Nat Immunol 2006; 7: 859–867.
- 22, , et al. Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b. Nucleic Acids Res 2005; 33: 987–998.
- 23, , et al. Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J Biol Chem 2004; 279: 40906–40917.
- 24, , et al. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med 2003; 197: 831–844.
- 25, , et al. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet 2002; 30: 295–300.
- 26, , et al. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J 2000; 19: 5845–5855.
- 27, , et al. Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection. EMBO J 1998; 17: 5349–5359.
- 28, , et al. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. Immunity 1997; 7: 155–162.
- 29, , et al. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404: 193–197.
- 30, , . Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997; 91: 661–672.
- 31, , et al. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death. Proc Natl Acad Sci USA 1996; 93: 14569–14573.
- 32, , et al. Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression. Oncogene 2007; 26: 3541–3550.
- 33, . Mitochondria and cell death: Outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 2010; 11: 621–632.
- 34, , et al. Drugs targeting Bcl-2 family members as an emerging strategy in cancer. Exp Rev Mol Med 2010; 12: e28.
- 35, , . Apoptosis: Embedded in membranes. Curr Opin Cell Biol 2010;22:845–851.
- 36, , . Still embedded together binding to membranes regulates Bcl-2 protein interactions. Oncogene 2010; 29: 5221–5230.
- 37, , et al. A variant allele of growth factor independence 1 (GFI1) is associated with acute myeloid leukemia. Blood 2010; 115: 2462–2472.
- 38, , et al. CD34, RAB20, Pu 1 and GFI1 mRNA expression in myelodysplastic syndrome. Int J Lab Hematol 2009; 31: 344–351.
- 39, , et al. Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity 2008; 28: 370–380.
- 40, , et al. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet 2003; 34: 308–312.
- 41, , et al. Neutrophil elastase in cyclic and severe congenital neutropenia. Blood 2007; 109: 1817– 1824.
- 42, , et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447: 725–729.
- 43, . How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007; 8: 703–713.