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Version of Record online: 5 APR 2011
Copyright © 2011 AlphaMed Press
Volume 29, Issue 4, pages 670–677, April 2011
How to Cite
Pandit, S. R., Sullivan, J. M., Egger, V., Borecki, A. A. and Oleskevich, S. (2011), Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss. STEM CELLS, 29: 670–677. doi: 10.1002/stem.609
Disclosure of potential conflicts of interest is found at the end of this article.
Author contributions: S.R.P.: conception and design, collection and assembly of data, data analysis and interpretation; J.M.S.: data analysis and interpretation, manuscript writing and final approval of manuscript; V.E.: collection and assembly of data; A.A.B.: collection and assembly of data; S.O.: conception and design, data analysis and interpretation, manuscript writing and final approval of manuscript. S.R.P. and J.M.S. are equal first authors to this article.
First published online in STEM CELLSEXPRESS February 10, 2011.
- Issue online: 5 APR 2011
- Version of Record online: 5 APR 2011
- Accepted manuscript online: 10 FEB 2011 09:29AM EST
- Manuscript Accepted: 12 JAN 2011
- Manuscript Received: 29 SEP 2010
- Australian Deafness Research Foundation
- Fairfax Foundation
- Auditory brainstem response;
- Auditory threshold;
- Cell therapy;
- Hearing loss;
- Inner ear;
- Olfactory stem cell
Transplantation of exogenous stem cells has been proposed as a treatment to prevent or reverse sensorineural hearing loss. Here, we investigate the effects of transplantation of adult human olfactory mucosa-derived stem cells on auditory function in A/J mice, a strain exhibiting early-onset progressive sensorineural hearing loss. Recent evidence indicates that these stem cells exhibit multipotency in transplantation settings and may represent a subtype of mesenchymal stem cell. Olfactory stem cells were injected into the cochleae of A/J mice via a lateral wall cochleostomy during the time period in which hearing loss first becomes apparent. Changes in auditory function were assessed 1 month after transplantation and compared against animals that received sham injections. Hearing threshold levels in stem cell-transplanted mice were found to be significantly lower than those of sham-injected mice (p < .05) for both click and pure tone stimuli. Transplanted cells survived within the perilymphatic compartments but did not integrate into cochlear tissues. These results indicate that transplantation of adult human olfactory mucosa-derived stem cells can help preserve auditory function during early-onset progressive sensorineural hearing loss. STEM Cells 2011;29:670–677