Concise Review: Stem Cells for the Treatment of Cerebellar-Related Disorders§

Authors

  • Slaven Erceg,

    Corresponding author
    1. CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa), Avda. Americo Vespucio s/n, Parque Científico y Tecnológico Cartuja, Sevilla, Spain
    2. Medical Genome Project, Edificio INSUR, Parque Científico y Tecnológico Cartuja, Sevilla, Spain
    • CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa), Avda. Americo Vespucio s/n, Parque Científico y Tecnológico Cartuja, Sevilla, Spain
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    • Ph: +34955402245; Fax: +34955040457

  • Victoria Moreno-Manzano,

    1. Neural Degeneration Lab, Centro de Investigación “Principe Felipe,” Valencia, Spain
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  • Marcela Garita-Hernandez,

    1. CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa), Avda. Americo Vespucio s/n, Parque Científico y Tecnológico Cartuja, Sevilla, Spain
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  • Miodrag Stojkovic,

    1. Spebo Medical, Leskovac, Serbia
    2. Human Genetics Department, Medical Faculty, University of Kragujevac, Serbia
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  • Shomi S. Bhattacharya

    1. CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa), Avda. Americo Vespucio s/n, Parque Científico y Tecnológico Cartuja, Sevilla, Spain
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  • Disclosure of potential conflicts of interest is found at the end of this article.

  • Author contributions: S.E.: conception and design, data analysis and interpretation, manuscript writing, final approval of manuscript, other (perform experiments and graphic design); V.M.-M.: other (perform experiments); M.G.-H.: other (perform experiments and graphic design); M.S. and S.S.B.: conception and design, manuscript writing, final approval of manuscript.

  • §

    First published online in STEM CELLSEXPRESS February 11, 2011; available online without subscription thorugh the open access option.

Abstract

Embryonic neural transplants have become clinically relevant over the past 25 years for their possible application in the treatment of cerebellum-related neurodegenerative diseases. While highlighting the important role that fetal neural progenitors have in meeting these challenges, we define rationales for all types of cell therapy involving adult stem cells as well as human embryonic stem cells (hESC) and human induced pluripotent stem (iPS) cells. The recent advances in the field of hESC and iPS cells, including their capacity for differentiation toward regional specific neural lineages, could open a new era of transplantation in cell-based therapy for cerebellar ataxias. STEM Cells 2011;29:564–569

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