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Keywords:

  • Adult stem cells;
  • Cell transplantation;
  • Cellular therapy;
  • Embryonic stem cells;
  • Neural differentiation;
  • Neural stem cell;
  • Fetal stem cells;
  • Stem cell transplantation

Abstract

Embryonic neural transplants have become clinically relevant over the past 25 years for their possible application in the treatment of cerebellum-related neurodegenerative diseases. While highlighting the important role that fetal neural progenitors have in meeting these challenges, we define rationales for all types of cell therapy involving adult stem cells as well as human embryonic stem cells (hESC) and human induced pluripotent stem (iPS) cells. The recent advances in the field of hESC and iPS cells, including their capacity for differentiation toward regional specific neural lineages, could open a new era of transplantation in cell-based therapy for cerebellar ataxias. STEM Cells 2011;29:564–569