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Concise Review: Quiescent and Active States of Endogenous Adult Neural Stem Cells: Identification and Characterization†‡§

  1. Ya-Zhou Wang1,2,¶,*,
  2. Jennifer M. Plane2,
  3. Peng Jiang2,
  4. Chengji J. Zhou2,‖,*,
  5. Wenbin Deng2,††,*

Article first published online: 23 MAY 2011

DOI: 10.1002/stem.644

Issue

STEM CELLS

STEM CELLS

Volume 29, Issue 6, pages 907–912, June 2011

Additional Information

How to Cite

Wang, Y.-Z., Plane, J. M., Jiang, P., Zhou, C. J. and Deng, W. (2011), Concise Review: Quiescent and Active States of Endogenous Adult Neural Stem Cells: Identification and Characterization. STEM CELLS, 29: 907–912. doi: 10.1002/stem.644

Author Information

  1. 1

    Cellular and Molecular Biology Laboratory, Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, China

  2. 2

    Department of Cell Biology and Human Anatomy, Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children, University of California-Davis, Sacramento, California, USA

  1. Telephone: (86) 29-84779090; Fax: (86∥ 29-83246270

  2. ‖

    Telephone: 916-453-2268; Fax: 916-453-2288

  3. ††

    Telephone: 916-453-2287; Fax: 916-453-2288

*Institute of Neurosciences, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China

  1. †

    Author contributions: Y.-Z.W.: conception, manuscript writing, financial support; J.M.P. and P.J.: conception, manuscript writing; C.J.Z.: conception, manuscript writing, financial support; W.D.: conception, manuscript writing, financial support, final approval of manuscript.

  2. ‡

    Disclosure of potential conflicts of interest is found at the end of this article.

  3. §

    First published online in STEM CELLSEXPRESS April 19, 2011

  4. Telephone: (86) 29-84779090; Fax: (86∥ 29-83246270

  5. ‖

    Telephone: 916-453-2268; Fax: 916-453-2288

  6. ††

    Telephone: 916-453-2287; Fax: 916-453-2288

Publication History

  1. Issue published online: 23 MAY 2011
  2. Article first published online: 23 MAY 2011
  3. Accepted manuscript online: 19 APR 2011 10:25AM EST
  4. Manuscript Accepted: 1 APR 2011
  5. Manuscript Received: 28 JAN 2011

Funded by

  • NIH. Grant Numbers: R01NS059043, R01ES015988, R01DE021696
  • Natural Science Foundation of China. Grant Number: 30800549
  • Shriners Postdoctoral Fellowships

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Keywords:

  • Quiescent neural stem cell;
  • Active neural stem cell;
  • Proliferation;
  • Differentiation;
  • Niche;
  • Regeneration

Abstract

The adult mammalian central nervous system (CNS) lacks the capacity for regeneration, making it a highly sought-after topic for researchers. The identification of neural stem cells (NSCs) in the adult CNS wiped out a long-held dogma that the adult brain contains a set number of neurons and is incapable of replacing them. The discovery of adult NSCs (aNSCs) stoked the fire for researchers who dream of brain self-repair. Unfortunately, the quiescent nature and limited plasticity of aNSCs diminish their regenerative potential. Recent studies evaluating aNSC plasticity under pathological conditions indicate that a switch from quiescent to active aNSCs in neurogenic regions plays an important role in both repairing the damaged tissue and preserving progenitor pools. Here, we summarize the most recent findings and present questions about characterizing the active and quiescent aNSCs in major neurogenic regions, and factors for maintaining their active and quiescent states, hoping to outline an emerging view for promoting the endogenous aNSC-based regeneration. STEM CELLS 2011;29:907–912

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