Concise Review: Challenging the Pluripotency of Human Testis-Derived ESC-like Cells§

Authors

  • Natalia Tapia,

    1. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany
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  • Marcos J. Araúzo-Bravo,

    1. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany
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  • Kinarm Ko,

    Corresponding author
    1. Center for Stem Cell Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea
    2. Department of Neuroscience, School of Medicine, Konkuk University, Seoul, Republic of Korea
    • Center for Stem Cell Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 143-701, Republic of Korea and Department of Neuroscience, School of Medicine, Konkuk University, Seoul 143-701, Republic of Korea
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    • Telephone: +822-2030-7888; Fax: +822-446-9001

  • Hans R. Schöler

    Corresponding author
    1. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany
    2. Faculty of Medicine, University of Münster, Münster, Germany
    • Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrae 20, 48149 Münster, Germany
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    • Telephone: 49-251-70365-300; Fax: 49-251-70365-399


  • Authors contributions: N.T.: conception and design, manuscript writing; M.J.A.-B.: manuscript editing; K.K.: final approval of manuscript; H.R.S.: conception and design, manuscript writing, and final manuscript approval.

  • Disclosure of potential conflicts of interest is found at the end of this article.

  • §

    First published online in STEM CELLS EXPRESS June 6, 2011.

Abstract

Several research groups have claimed to have successfully generated pluripotent or multipotent cells from human testis. However, the pluripotent character of those cells with respect to gene expression profile and ability to generate teratomas has been called into question. Here, we critically review these reports and provide insight to guide future studies on the derivation of human pluripotent cells from testicular tissue. STEM CELLS 2011;29:1165–1169

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