• 1
    Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 9647.
  • 2
    Shi Q, Rafii S, Wu MH et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998; 92: 362367.
  • 3
    Asahara T, Masuda H, Takahashi T et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85: 221228.
  • 4
    Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267: 1093110934.
  • 5
    Risau W, Sariola H, Zerwes HG et al. Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development 1988; 102: 471478.
  • 6
    Isner JM, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest 1999; 103: 12311236.
  • 7
    Bailey AS, Jiang S, Afentoulis M et al. Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood 2004; 103: 1319.
  • 8
    Pelosi E, Valtieri M, Coppola S et al. Identification of the hemangioblast in postnatal life. Blood 2002; 100: 32033208.
  • 9
    Grant MB, May WS, Caballero S et al. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nat Med 2002; 8: 607612.
  • 10
    Ingram DA, Caplice NM, Yoder MC. Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood 2005; 106: 15251531.
  • 11
    Aicher A, Rentsch M, Sasaki K et al. Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res 2007; 100: 581589.
  • 12
    Timmermans F, Van Hauwermeiren F, De Smedt M et al. Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors. Arterioscler Thromb Vasc Biol 2007; 27: 15721579.
  • 13
    Flamme I, Risau W. Induction of vasculogenesis and hematopoiesis in vitro. Development 1992; 116: 435439.
  • 14
    Timmermans F, Plum J, Yoder MC et al. Endothelial progenitor cells: Identity defined? J Cell Mol Med 2009; 13: 87102.
  • 15
    Masuda H, Alev C, Akimaru H et al. Methodological development of a clonogenic assay to determine endothelial progenitor cell potential. Circ Res 2011; 109: 2037.
  • 16
    Kwon SM, Eguchi M, Wada M et al. Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization. Circulation 2008; 118: 157165.
  • 17
    Tanaka R, Wada M, Kwon SM et al. The effects of flap ischemia on normal and diabetic progenitor cell function. Plast Reconstr Surg 2008; 121: 19291942.
  • 18
    Kamei N, Kwon SM, Alev C et al. Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury. Stem Cells 2010; 28: 365375.
  • 19
    Dimmeler S, Aicher A, Vasa M et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001; 108: 391397.
  • 20
    Takahashi T, Kalka C, Masuda H et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999; 5: 434438.
  • 21
    Vasa M, Fichtlscherer S, Aicher A et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001; 89: E1E7.
  • 22
    Kalka C, Masuda H, Takahashi T et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000; 97: 34223427.
  • 23
    Murohara T, Ikeda H, Duan J et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest 2000; 105: 15271536.
  • 24
    Sharpe EE,3rd, Teleron AA, Li B et al. The origin and in vivo significance of murine and human culture-expanded endothelial progenitor cells. Am J Pathol 2006; 168: 17101721.
  • 25
    Gulati R, Jevremovic D, Peterson TE et al. Diverse origin and function of cells with endothelial phenotype obtained from adult human blood. Circ Res 2003; 93: 10231025.
  • 26
    Hur J, Yang HM, Yoon CH et al. Identification of a novel role of T cells in postnatal vasculogenesis: Characterization of endothelial progenitor cell colonies. Circulation 2007; 116: 16711682.
  • 27
    Rehman J, Li J, Orschell CM et al. Peripheral blood “endothelial progenitor cells” are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003; 107: 11641169.
  • 28
    Shepherd RM, Capoccia BJ, Devine SM et al. Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood 2006; 108: 36623667.
  • 29
    Bailey AS, Willenbring H, Jiang S et al. Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci USA 2006; 103: 1315613161.
  • 30
    Romagnani P, Annunziato F, Liotta F et al. CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors. Circ Res 2005; 97: 314322.
  • 31
    Moldovan NI. Role of monocytes and macrophages in adult angiogenesis: A light at the tunnel's end. J Hematother Stem Cell Res 2002; 11: 179194.
  • 32
    Lin Y, Weisdorf DJ, Solovey A et al. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000; 105: 7177.
  • 33
    Ingram DA, Mead LE, Tanaka H et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004; 104: 27522760.
  • 34
    Hur J, Yoon CH, Kim HS et al. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 2004; 24: 288293.
  • 35
    Sieveking DP, Buckle A, Celermajer DS et al. Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: Insights from a novel human angiogenesis assay. J Am Coll Cardiol 2008; 51: 660668.
  • 36
    Wojakowski W, Kucia M, Kazmierski M et al. Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: Relevant reparatory mechanism? Heart 2008; 94: 2733.
  • 37
    Losordo DW, Kishore R. A big promise from the very small identification of circulating embryonic stem-like pluripotent cells in patients with acute myocardial infarction. J Am Coll Cardiol 2009; 53: 1012.
  • 38
    Masuda H, Kalka C, Takahashi T et al. Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis. Circ Res 2007; 101: 598606.
  • 39
    Bauer SM, Goldstein LJ, Bauer RJ et al. The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia. J Vasc Surg 2006; 43: 134141.
  • 40
    Ii M, Nishimura H, Iwakura A et al. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via “imported” nitric oxide synthase activity. Circulation 2005; 111: 11141120.
  • 41
    Iwakura A, Shastry S, Luedemann C et al. Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 2006; 113: 16051614.
  • 42
    Murayama T, Tepper OM, Silver M et al. Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo. Exp Hematol 2002; 30: 96772.
  • 43
    Urbich C, Aicher A, Heeschen C et al. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 2005; 39: 733742.
  • 44
    Dai Y, Ashraf M, Zuo S et al. Mobilized bone marrow progenitor cells serve as donors of cytoprotective genes for cardiac repair. J Mol Cell Cardiol 2008; 44: 607617.
  • 45
    Kawamoto A, Asahara T, Losordo DW. Transplantation of endothelial progenitor cells for therapeutic neovascularization. Cardiovasc Radiat Med 2002; 3: 221225.
  • 46
    Wu Y, Ip JE, Huang J et al. Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circ Res 2006; 99: 315322.
  • 47
    Jujo K, Ii M, Losordo DW. Endothelial progenitor cells in neovascularization of infarcted myocardium. J Mol Cell Cardiol 2008; 45: 530544.
  • 48
    Miyamoto Y, Suyama T, Yashita T et al. Bone marrow subpopulations contain distinct types of endothelial progenitor cells and angiogenic cytokine-producing cells. J Mol Cell Cardiol 2007; 43: 627635.
  • 49
    Kocher AA, Schuster MD, Szabolcs MJ et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430436.
  • 50
    Aicher A, Brenner W, Zuhayra M et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003; 107: 21342139.
  • 51
    Kawamoto A, Gwon HC, Iwaguro H et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001; 103: 634637.
  • 52
    Kawamoto A, Iwasaki H, Kusano K et al. CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells. Circulation 2006; 114: 21632169.
  • 53
    Schatteman GC, Hanlon HD, Jiao C et al. Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice. J Clin Invest 2000; 106: 571578.
  • 54
    Iwasaki H, Kawamoto A, Ishikawa M et al. Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction. Circulation 2006; 113: 13111325.
  • 55
    Burt RK, Testori A, Oyama Y et al. Autologous peripheral blood CD133+ cell implantation for limb salvage in patients with critical limb ischemia. Bone Marrow Transplant 2010; 45: 1111116.
  • 56
    Kawamoto A, Katayama M, Handa N et al. Intramuscular transplantation of G-CSF-mobilized CD34(+) cells in patients with critical limb ischemia: a phase I/IIa, multicenter, single-blinded, dose-escalation clinical trial. Stem Cells 2009; 27: 28572864.
  • 56
    Schachinger V, Assmus B, Britten MB et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol 2004; 44: 16901699.
  • 57
    Bartunek J, Vanderheyden M, Vandekerckhove B et al. Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: Feasibility and safety. Circulation 2005; 112( 9 suppl): I178I183.
  • 58
    Li ZQ, Zhang M, Jing YZ et al. The clinical study of autologous peripheral blood stem cell transplantation by intracoronary infusion in patients with acute myocardial infarction (AMI). Int J Cardiol 2007; 115: 5256.
  • 59
    Stamm C, Westphal B, Kleine HD et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003; 361: 4546.
  • 60
    Stamm C, Kleine HD, Choi YH et al. Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: Safety and efficacy studies. J Thorac Cardiovasc Surg 2007; 133: 717725.
  • 61
    Boyle AJ, Whitbourn R, Schlicht S et al. Intra-coronary high-dose CD34+ stem cells in patients with chronic ischemic heart disease: A 12-month follow-up. Int J Cardiol 2006; 109: 2127.
  • 62
    Losordo DW, Schatz RA, White CJ et al. Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: A phase I/IIa double-blind, randomized controlled trial. Circulation 2007; 115: 31653172.
  • 64
    Kuroda R, Matsumoto T, Miwa M et al. Local Transplantation of G-CSF-mobilized CD34+ cells in a patient with tibial nonunion: A case report. Cell Transplant 2010 [Epub ahead of print].
  • 65
    Hung HS, Shyu WC, Tsai CH et al. Transplantation of endothelial progenitor cells as therapeutics for cardiovascular diseases. Cell Transplant 2009; 18: 10031012.
  • 66
    Heiss C, Keymel S, Niesler U et al. Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol 2005; 45: 14411448.
  • 67
    Ii M, Takenaka H, Asai J et al. Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury. Circ Res 2006; 98: 697704.
  • 68
    Imanishi T, Moriwaki C, Hano T et al. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. J Hypertens 2005; 23: 18311837.
  • 69
    Kondo T, Hayashi M, Takeshita K et al. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 2004; 24: 14421447.
  • 70
    Michaud SE, Dussault S, Haddad P et al. Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities. Atherosclerosis 2006; 187: 423432.
  • 71
    Pesce M, Orlandi A, Iachininoto MG et al. Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues. Circ Res 2003; 93: e51e62.
  • 72
    Ott I, Keller U, Knoedler M et al. Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction. FASEB J 2005; 19: 992994.