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STEM_747_sm_supplFig1.pdf42KSupp Figure 1. BrdU+ label-retaining cells are observed in the adult and aged SVZ. Representative images from the subventricular zones of 3mo (A) and 20mo (B) mice injected with 50mg/kg BrdU intraperitoneally for 12 days, then sacrificed after a latency of 28 days. BrdU is labeled in green, SOX2 in red, GFAP in blue; the line indicates 20μm. 45% fewer BrdU+ labelretaining cells are observed in the aged SVZ, compared with young SVZ (C, p<0.05). Fewer BrdU-retaining aged cells colabel with NPC markers SOX2 (D, p<0.01); no significant change was observed in BrdU+GFAP+ cells (D, p>0.05).
STEM_747_sm_supplFig2.tif750KSupp Figure 2. Number of model-predicted and actual BrdU+ cells over 12 days in vivo.
STEM_747_sm_supplFig3.tif2082KSupp Figure 3. Schematic describing age-related neurogenic decline. The aged SVZ contains a smaller population of stem-like cells, which give rise to progenitor cells. Aged progenitors undergo more rounds of cell division over time than young progenitors, expanding this population, which is pared down again by decreased survival and neuronal differentiation (shown with X's).
STEM_747_sm_suppltable1.tif599KSupp Table 1. Summary of data incorporated into in vitro mathematical model.
STEM_747_sm_suppltable2.tif863KSupp Table 2. Summary of data incorporated into in vivo mathematical model.
STEM_747_sm_supplinfo.pdf110KSupplementary Data

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