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Article first published online: 16 NOV 2011
Copyright © 2011 AlphaMed Press
Volume 29, Issue 12, pages 1923–1932, December 2011
How to Cite
O'Callaghan, A. R. and Daniels, J. T. (2011), Concise Review: Limbal Epithelial Stem Cell Therapy: Controversies and Challenges. STEM CELLS, 29: 1923–1932. doi: 10.1002/stem.756
Author contributions: A.O.C.: collection and/or assembly of data, data analysis and interpretation, and manuscript writing; J.T.D.: manuscript writing, and final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS October 13, 2011.
- Issue published online: 16 NOV 2011
- Article first published online: 16 NOV 2011
- Accepted manuscript online: 13 OCT 2011 09:36AM EST
- Manuscript Accepted: 18 SEP 2011
- Manuscript Received: 29 JUN 2011
- UCL Institute of Ophthalmology and Moorfields Eye Hospital
- Corneal epithelium;
- Stem cell niche;
- Stem cells;
- Cultured cells;
- corneal diseases
Limbal epithelial stem cells (LESCs) are a population of stem cells responsible for maintenance and repair of the corneal surface. Injury and disease can result in a deficiency of these stem cells, the vision affecting condition called limbal stem cell deficiency (LSCD) in which the cornea becomes opaque, vascularized, and inflamed. Cultured LESC therapy was first described in 1997;29:19231932–19231932.and LESCs cultured from either patients or donors have been used to successfully treat LSCD. In this review, some of the challenges and controversies associated with cultured LESC therapy will be discussed including alternative stem cell sources. STEM CELLS 2011;29:1923-1932