Telephone: +98 21 22306485; Fax: +98 21 23562507
Article first published online: 16 NOV 2011
Copyright © 2011 AlphaMed Press
Volume 29, Issue 12, pages 1933–1941, December 2011
How to Cite
Pournasr, B., Khaloughi, K., Salekdeh, G. H., Totonchi, M., Shahbazi, E. and Baharvand, H. (2011), Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells. STEM CELLS, 29: 1933–1941. doi: 10.1002/stem.760
Author contributions: B.P. and K.K.: collection and assembly of data, data analysis and interpretation, and manuscript writing; G.H.S.: data analysis and interpretation and manuscript writing; M.T. and E.S.: collection and assembly of data and data analysis and interpretation; and H.B.: conception and design, administrative support, manuscript writing, and final approval of the manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS October 13, 2011.
- Issue published online: 16 NOV 2011
- Article first published online: 16 NOV 2011
- Accepted manuscript online: 13 OCT 2011 09:40AM EST
- Manuscript Accepted: 25 SEP 2011
- Manuscript Received: 27 JUL 2011
- Royan Institute and Iranian Council of Stem Cell Technology
- Transcription factor
A major goal of regenerative medicine is to produce cells to participate in the generation, maintenance, and repair of tissues that are damaged by disease, aging, or trauma, such that function is restored. The establishment of induced pluripotent stem cells, followed by directed differentiation, offers a powerful strategy for producing patient-specific therapies. Given how laborious and lengthy this process can be, the conversion of somatic cells into lineage-specific stem/progenitor cells in one step, without going back to, or through, a pluripotent stage, has opened up tremendous opportunities for regenerative medicine. However, there are a number of obstacles to overcome before these cells can be widely considered for clinical applications. Here, we focus on induced transdifferentiation strategies to convert mature somatic cells to other mature cell types or progenitors, and we summarize the challenges that need to be met if the potential applications of transdifferentiation technology are to be achieved. STEM Cells 2011;29:1933–1941.