Concise Review: A Chemical Approach to Control Cell Fate and Function§

Authors

  • Wenlin Li,

    1. Department of Chemistry, The Scripps Research Institute, San Diego, California, USA
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  • Kai Jiang,

    1. Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
    2. Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA
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  • Sheng Ding

    Corresponding author
    1. Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
    2. Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA
    • Gladstone Institute of Cardiovascular Disease and Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
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    • Telephone: 415-734-2717, Fax: 415-355-0141


  • Author contributions: W.L. and K.J.: manuscript writing, S.D.: manuscript writing and conception and design.

  • Disclosure of potential conflicts of interest is found at the end of this article.

  • §

    First published online in STEM CELLSEXPRESS October 25, 2011.

Abstract

Stem cells are essential for maintaining tissue homeostasis and mediating physiological and pathological regeneration. Recent breakthroughs in stem cell biology have generated tremendous enthusiasm and hope for the therapeutic potential of stem cells in regenerative medicine. However, this research is still in an early development stage. An improved understanding of stem cell biology is required to precisely manipulate stem cell fate and to harness these cells for regenerative medicine. Small molecules, targeting specific signaling pathways and mechanisms, are powerful tools for manipulating stem cells for desired outcomes. Those small molecules are increasingly important in probing the fundamental mechanisms of stem cell biology and facilitating the development of therapeutic approaches for regenerative medicine. These could involve cell replacement therapies with homogenous functional cells produced under chemically defined conditions in vitro and the development of small-molecule drugs that modulate patient's endogenous cells for therapeutic benefit. STEM CELLS2012;30:61–68

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