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STEM CELLS

Cover image for Vol. 34 Issue 1

January 2016

Volume 34, Issue 1

Pages 1–252

  1. Issue Information-Ed Board

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Issue Information-Ed Board (pages 1–2)

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2126

  2. Issue Information-Copyright

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Issue Information-Copyright (page 3)

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2128

  3. Issue Information-Mission & Focus

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Issue Information-Mission & Focus (page 4)

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2129

  4. Issue Information-TOC

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Issue Information-TOC (pages 5–8)

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2127

  5. Issue Information-Forthcoming Articles

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Issue Information-Forthcoming Articles (page 10)

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2130

  6. Editorial

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
    1. You have free access to this content
  7. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
    1. You have free access to this content
    2. You have free access to this content
  8. Regenerative Medicine

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Concise Review: Pluripotent Stem Cell-Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand? (pages 34–43)

      Elodie Gouadon, Thomas Moore-Morris, Nicoline W. Smit, Lucienne Chatenoud, Ruben Coronel, Sian E. Harding, Philippe Jourdon, Virginie Lambert, Catherine Rucker-Martin and Michel Pucéat

      Article first published online: 16 SEP 2015 | DOI: 10.1002/stem.2205

  9. Translational and Clinical Research

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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  10. Cancer Stem Cells

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
    1. You have full text access to this OnlineOpen article
      LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway (pages 55–66)

      Mingli Zhou, Yixuan Hou, Guanglun Yang, Hailong Zhang, Gang Tu, Yan-e Du, Siyang Wen, Liyun Xu, Xi Tang, Shifu Tang, Li Yang, Xiaojiang Cui and Manran Liu

      Article first published online: 17 NOV 2015 | DOI: 10.1002/stem.2219

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      P-Selectin Sustains Extramedullary Hematopoiesis in the Gata1low Model of Myelofibrosis (pages 67–82)

      Gerald J. Spangrude, Daniel Lewandowski, Fabrizio Martelli, Manuela Marra, Maria Zingariello, Laura Sancillo, Rosa Alba Rana and Anna Rita Migliaccio

      Article first published online: 23 OCT 2015 | DOI: 10.1002/stem.2229

      Thumbnail image of graphical abstract

      There is not a single culprit. The data presented in this manuscript suggest that in the Gata1low model, myelofibrotic stem cells are sustained in the spleen by a niche formed by the interaction of at least three distinctive cell populations. First neutrophils establish a P-selectin dependent interaction with megakaryocytes that leads to release of TGF-β. TGF-β induces the transition of a resident spleen cell population to activated fibrocytes which in turn interact with their protrusions with the megakaryocytes creating a super-cellular structure that hosts, and possibly supports, the proliferation of myelofibrotic stem cells in the spleen. See legend of Figure 7 for further details

  11. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming (pages 83–92)

      Yi Wu, Keshi Chen, Xiyin Liu, Lili Huang, Danyun Zhao, Linpeng Li, Mi Gao, Duanqing Pei, Chenguang Wang and Xingguo Liu

      Article first published online: 29 SEP 2015 | DOI: 10.1002/stem.2209

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      Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer (pages 93–101)

      David L. Hermanson, Laura Bendzick, Lee Pribyl, Valarie McCullar, Rachel Isaksson Vogel, Jeff S. Miller, Melissa A. Geller and Dan S. Kaufman

      Article first published online: 6 DEC 2015 | DOI: 10.1002/stem.2230

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      MiR-126 Contributes to Human Umbilical Cord Blood Cell-Induced Neurorestorative Effects After Stroke in Type-2 Diabetic Mice (pages 102–113)

      Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang and Michael Chopp

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2193

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      MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration (pages 124–134)

      Akshay Bhinge, Seema C. Namboori, Angela Bithell, Chiara Soldati, Noel J. Buckley and Lawrence W. Stanton

      Article first published online: 20 NOV 2015 | DOI: 10.1002/stem.2233

  12. Regenerative Medicine

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
    1. You have free access to this content
    2. You have full text access to this OnlineOpen article
      Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase (pages 148–159)

      Motoi Okada, Ha Won Kim, Kaoru Matsu-ura, Yi-Gang Wang, Meifeng Xu and Muhammad Ashraf

      Article first published online: 9 OCT 2015 | DOI: 10.1002/stem.2211

    3. You have full text access to this OnlineOpen article
      Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation (pages 160–173)

      Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan and Mari Dezawa

      Article first published online: 28 SEP 2015 | DOI: 10.1002/stem.2206

  13. Tissue-Specific Stem Cells

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Cell Adhesion Molecules and Stem Cell-Niche-Interactions in the Limbal Stem Cell Niche (pages 203–219)

      Naresh Polisetti, Matthias Zenkel, Johannes Menzel-Severing, Friedrich E. Kruse and Ursula Schlötzer-Schrehardt

      Article first published online: 11 SEP 2015 | DOI: 10.1002/stem.2191

      Thumbnail image of graphical abstract

      Laser confocal image of limbal epithelial progenitor cell cluster comprising cytokeratin 15 (CK15)-positive epithelial progenitor cells (turquoise) and associated niche cells, i.e. Melan-A-positive melanocytes (yellow-green) and vimentin-positive subepithelial stromal cells (red) and intraepithelial immune cells (red); nuclei are counterstained with DAPI (blue).

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      miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network (pages 220–232)

      Márcia C. T. Santos, Allison N. Tegge, Bruna R. Correa, Swetha Mahesula, Luana Q. Kohnke, Mei Qiao, Marco A. R. Ferreira, Erzsebet Kokovay and Luiz O. F. Penalva

      Article first published online: 15 SEP 2015 | DOI: 10.1002/stem.2204

    5. You have full text access to this OnlineOpen article
      DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro (pages 233–245)

      Deborah Roidl, Nicole Hellbach, Patrick P. Bovio, Alejandro Villarreal, Stefanie Heidrich, Sigrun Nestel, Björn A. Grüning, Ulrike Boenisch and Tanja Vogel

      Article first published online: 29 SEP 2015 | DOI: 10.1002/stem.2187

  14. Embryonic Stem Cells/Induced Pluripotent Stem Cells

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
    1. You have full text access to this OnlineOpen article
      Brief Report: Inhibition of miR-145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells (pages 246–251)

      Tomas Barta, Lucie Peskova, Joseph Collin, David Montaner, Irina Neganova, Lyle Armstrong and Majlinda Lako

      Article first published online: 9 OCT 2015 | DOI: 10.1002/stem.2220

  15. Corrigendum

    1. Top of page
    2. Issue Information-Ed Board
    3. Issue Information-Copyright
    4. Issue Information-Mission & Focus
    5. Issue Information-TOC
    6. Issue Information-Forthcoming Articles
    7. Editorial
    8. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    9. Regenerative Medicine
    10. Translational and Clinical Research
    11. Cancer Stem Cells
    12. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    13. Regenerative Medicine
    14. Tissue-Specific Stem Cells
    15. Embryonic Stem Cells/Induced Pluripotent Stem Cells
    16. Corrigendum
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      Corrigendum (page 252)

      Article first published online: 13 JAN 2016 | DOI: 10.1002/stem.2236

      This article corrects:

      Systemic Anticancer Neural Stem Cells in Combination with a Cardiac Glycoside for Glioblastoma Therapy

      Vol. 32, Issue 8, 2021–2032, Article first published online: 15 JUL 2014

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