Although fraught with complexity, the self is a central phenomenon of discussion and analysis within sociology. This article contributes to this discourse by introducing the Buddhist ideas of anatta (no-self) and prattyasamutpāda (interdependence) as analytic frameworks to deconstruct and rethink the self within sociology. We argue that the sociological self, most clearly articulated by symbolic interactionism, is premised on a self-other dualism. This dualism leads to a conceptualization of the self as constantly threatened and anxious. Using these Buddhist concepts we propose an alternative interpretive schema, a sociology of no-self, for analyzing social interaction and understanding the roots of social angst.