The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse
Article first published online: 9 DEC 2002
Copyright © 2003 Wiley-Liss, Inc.
Volume 47, Issue 3, pages 240–242, 1 March 2003
How to Cite
McGeehan, A. J. and Olive, M. F. (2003), The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse, 47: 240–242. doi: 10.1002/syn.10166
- Issue published online: 9 DEC 2002
- Article first published online: 9 DEC 2002
- Manuscript Accepted: 30 SEP 2002
- Manuscript Received: 25 JUN 2002
- State of California for medical research on alcohol and substance abuse through the University of California at San Francisco
- conditioned place preference;
We examined the ability of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of the type 5 metabotropic glutamate receptor (mGluR5), to reduce the rewarding effects of various drugs of abuse in the conditioned place preference (CPP) paradigm. Mice were treated with MPEP (1, 5, and 20 mg/kg i.p.) 10 min prior to cocaine (15 mg/kg i.p.), D-amphetamine (2 mg/kg i.p.), nicotine (0.5 mg/kg i.p.), morphine (5 mg/kg i.p.), or ethanol (2 g/kg i.p.) on 3 successive days of CPP conditioning trials. MPEP pretreatment dose-dependently reduced the development of CPP for cocaine only. When tested alone at the doses effective in reducing CPP, MPEP produced neither a place preference nor aversion. These data provide further support for a role of the mGluR5 receptor in the rewarding effects of cocaine. Synapse 47:240–242, 2003. © 2002 Wiley-Liss, Inc.