PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy
Article first published online: 30 NOV 2005
Copyright © 2005 Wiley-Liss, Inc.
Volume 59, Issue 2, pages 119–121, February 2006
How to Cite
Mirrione, M. M., Schiffer, W. K., Siddiq, M., Dewey, S. L. and Tsirka, S. E. (2006), PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse, 59: 119–121. doi: 10.1002/syn.20216
- Issue published online: 30 NOV 2005
- Article first published online: 30 NOV 2005
- Manuscript Accepted: 3 AUG 2005
- Manuscript Received: 11 JUL 2005
- The Department of Energy. Grant Number: OBER DE-AC02-98CH10886
- NIH. Grant Number: R01NS042168
- AHA-EIA. Grant Number: 0540107N
- The Klingenstein Foundation
Here we present the first demonstration that 2-deoxy-2[18F]fluoro-D-glucose (18FDG) and micro Positron Emission Tomography (μPET) can be used successfully to monitor regional changes in brain metabolism during acute seizure induction in C57Bl/6 mice. These longitudinal studies show a significant increase in 18FDG uptake in the hippocampus (33.2%) which correlates directly with seizure severity (R2 = 0.86). 18FDG μPET can potentially be used to monitor the development of TLE in mouse models from the acute phase of status epilepticus to the chronic phase of spontaneous recurrent seizures. These studies provide a foundation upon which we can begin to identify genetic contributions to the metabolic signature of TLE in mice, since many transgenics are in the C57Bl/6 background strain. Synapse 59: 119–121, 2006. © 2005 Wiley-Liss, Inc.