Post-pubertal emergence of alterations in locomotor activity in stop null mice
Article first published online: 8 JUN 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 61, Issue 9, pages 689–697, September 2007
How to Cite
Bégou, M., Brun, P., Bertrand, J.-B., Job, D., Schweitzer, A., D'Amato, T., Saoud, M., Andrieux, A. and Suaud-Chagny, M.-F. (2007), Post-pubertal emergence of alterations in locomotor activity in stop null mice. Synapse, 61: 689–697. doi: 10.1002/syn.20409
- Issue published online: 8 JUN 2007
- Article first published online: 8 JUN 2007
- Manuscript Accepted: 23 JAN 2007
- Manuscript Received: 22 SEP 2006
Overt schizophrenia is preceded by a prodromal phase during which juvenile patients display attenuated schizophrenia-related symptoms. Here, we have looked for evidence of a prodromal phase in juvenile STOP null mice, which, during adulthood, imitate features of schizophrenia. We have principally examined locomotor activity, which is abnormal in adult STOP null mice, and its apparent relationship with perturbed glutamatergic and dopaminergic transmission. When compared to corresponding wild-type mice, juvenile STOP null mice did not exhibit the basal hyperlocomotion or locomotor hypersensitivity to mild stress observed in adult mice. Juvenile STOP null mice also lacked disturbed locomotor sensitivity to MK-801, which was evident in adult mice. In contrast, juvenile STOP null mice exhibited a similar hypersensitivity to amphetamine as that found in adult mice. Thus, STOP null mice exhibited both a progression of locomotor activity defects over time and subtle alterations in the prepubertal period. We suggest that the pattern of locomotor disturbances observed in this study is related to altered dopaminergic reactivity in juvenile mice without major disturbance in glutamatergic transmission, whereas both neurotransmitter systems are impaired in adult mice. Synapse 61:689–697, 2007. © 2007 Wiley-Liss, Inc.