Dietary restriction modulates α-synuclein expression in the aging rat cortex and hippocampus
Article first published online: 13 JUN 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 61, Issue 9, pages 790–794, September 2007
How to Cite
Mladenovic, A., Perovic, M., Tanic, N., Petanceska, S., Ruzdijic, S. and Kanazir, S. (2007), Dietary restriction modulates α-synuclein expression in the aging rat cortex and hippocampus. Synapse, 61: 790–794. doi: 10.1002/syn.20427
- Issue published online: 13 JUN 2007
- Article first published online: 13 JUN 2007
- Manuscript Accepted: 27 MAR 2007
- Manuscript Revised: 13 MAR 2007
- Manuscript Received: 22 DEC 2006
- Ministry of Science and Environmental Protection of Republic of Serbia. Grant Number: 143004
- dietary restriction;
- Real Time RT-PCR;
Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of α-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of α-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of α-synuclein expression. Synapse 61:790–794, 2007. © 2007 Wiley-Liss, Inc.