Short Communication

Dietary restriction modulates α-synuclein expression in the aging rat cortex and hippocampus

  1. Aleksandra Mladenovic1,
  2. Milka Perovic1,
  3. Nikola Tanic1,
  4. Suzana Petanceska2,†,
  5. Sabera Ruzdijic1,
  6. Selma Kanazir1,*

Article first published online: 13 JUN 2007

DOI: 10.1002/syn.20427

Issue

Synapse

Synapse

Volume 61, Issue 9, pages 790–794, September 2007

Additional Information

How to Cite

Mladenovic, A., Perovic, M., Tanic, N., Petanceska, S., Ruzdijic, S. and Kanazir, S. (2007), Dietary restriction modulates α-synuclein expression in the aging rat cortex and hippocampus. Synapse, 61: 790–794. doi: 10.1002/syn.20427

Author Information

  1. 1

    Institute for Biological Research, Bul. Despota Stefana 142, 11 060 Belgrade, Serbia

  2. 2

    Nathan Kline Institute, New York University, Orangeburg, New York 10962

  1. †

    National Institute on Aging, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA.

*Laboratory of Molecular Neurobiology, Department of Neurobiology, Institute for Biological Research “Sinisa Stankovic,” University of Belgrade, Bul. Despota Stefana 142, 11 060 Belgrade, Serbia

Publication History

  1. Issue published online: 13 JUN 2007
  2. Article first published online: 13 JUN 2007
  3. Manuscript Accepted: 27 MAR 2007
  4. Manuscript Revised: 13 MAR 2007
  5. Manuscript Received: 22 DEC 2006

Funded by

  • Ministry of Science and Environmental Protection of Republic of Serbia. Grant Number: 143004

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (208K)

Keywords:

  • α-synuclein;
  • aging;
  • dietary restriction;
  • Real Time RT-PCR;
  • cortex;
  • hippocampus

Abstract

Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of α-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of α-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of α-synuclein expression. Synapse 61:790–794, 2007. © 2007 Wiley-Liss, Inc.

Get PDF (208K)