Prenatal stress alters limbo-corticostriatal homer protein expression
Article first published online: 13 AUG 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 61, Issue 11, pages 938–941, November 2007
How to Cite
Ary, A. W., Aguilar, V. R., Szumlinski, K. K. and Kippin, T. E. (2007), Prenatal stress alters limbo-corticostriatal homer protein expression. Synapse, 61: 938–941. doi: 10.1002/syn.20439
- Issue published online: 13 AUG 2007
- Article first published online: 13 AUG 2007
- Manuscript Accepted: 29 APR 2007
- Manuscript Received: 4 FEB 2007
- NARSAD Young Investigator Awards
- Santa Barbara Cottage Hospital Special Research Award
- limbic system
Early environmental stress influences developmental processes resulting in alterations in behavior and brain function, including abnormalities in glutamate neurotransmission. Here, we assessed the influence of prenatal stress on limbo-corticostriatal expression of Homer proteins that are critical elements in glutamatergic signaling. Pregnant, female Sprague–Dawley rats were subjected to either no treatment or to restraint stress 3 times per day for the last 7 days of gestation. At 21 d of age, offspring were sacrificed and brain tissue was rapidly extracted. Immunoblotting revealed regionally specific increases in certain Homer protein isoforms within prefrontal cortex and limbic structures, whereas the striatum exhibited a reduction in Homer 1a levels. These findings indicate that stress during development can produce enduring perturbations in Homer protein expression that likely contribute to glutamatergic and behavioral abnormalities observed following early environmental stress. Synapse 61:938–941, 2007. © 2007 Wiley-Liss, Inc.