Visualizing vesicular dopamine dynamics in Parkinson's disease
Version of Record online: 23 APR 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 63, Issue 8, pages 713–716, August 2009
How to Cite
de la Fuente-Fernández, R., Sossi, V., McCormick, S., Schulzer, M., Ruth, T. J. and Stoessl, A. J. (2009), Visualizing vesicular dopamine dynamics in Parkinson's disease. Synapse, 63: 713–716. doi: 10.1002/syn.20653
- Issue online: 23 APR 2009
- Version of Record online: 23 APR 2009
- Manuscript Accepted: 26 DEC 2008
- Manuscript Received: 19 SEP 2008
- Canadian Institutes of Health Research
- British Columbia Health Research Foundation
- Pacific Parkinson's Research Institute
- Michael Smith Foundation for Health Research
- TRIUMF Life Science grant
It has been suggested that dopamine derived from exogenous levodopa may not follow vesicular dynamics in Parkinson's disease (PD). Using a novel PET method based on the sensitivity of [11C]-dihydrotetrabenazine (DTBZ) binding to changes in vesicular dopamine levels, we show here that striatal [11C]-DTBZ binding decreases after levodopa administration in advanced PD, likely reflecting an increase in vesicular dopamine levels. Endogenous dopamine and exogenously derived dopamine seem to follow the same vesicular dynamics. Synapse 63:713–716, 2009. © 2009 Wiley-Liss, Inc.