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Keywords:

  • cocaine;
  • conditioned place preference;
  • type 1 inositol-1,4,5-triphosohate receptors;
  • 2-APB;
  • xestospongin C;
  • dopamine receptors

Abstract

Recent study shows that type 1 inositol-1,4,5-triphosohate receptors (IP3Rs) may be involved in amphetamine-induced conditioned preference, but little is known about its role in psychological dependence on cocaine. This study investigated the role and regulation of IP3R-1 in mice with cocaine-induced place preference. The cocaine-induced place preference was dose-dependently inhibited by intracerebroventricular pretreatment with IP3R antagonists, 2-aminophenoxyethane-borate (2-APB), and xestospongin C. The levels of IP3R-1 in the frontal cortex and nucleus accumbens of cocaine-conditioned mice significantly increased, which was completely abolished by SCH23390 and sulpiride, selective dopamine D1 and D2 receptor antagonists, respectively. These findings suggest that IP3R-1-mediated intracellular signaling pathway may play an important role in the development of cocaine-induced place preference and that the expression of IP3R-1 is controlled by both dopamine D1 and D2 receptors in the frontal cortex and nucleus accumbens of mice with cocaine-induced place preference. Synapse, 2012. © 2011 Wiley Periodicals, Inc.