Luke S. Poth and Bryan P. O'Connell contributed equally to this work.
Nomifensine alters sex differences in striatal dopaminergic function
Article first published online: 17 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 66, Issue 8, pages 686–693, August 2012
How to Cite
Poth, L. S., O'connell, B. P., Mcdermott, J. L. and Dluzen, D. E. (2012), Nomifensine alters sex differences in striatal dopaminergic function. Synapse, 66: 686–693. doi: 10.1002/syn.21554
- Issue published online: 2 JUN 2012
- Article first published online: 17 APR 2012
- Accepted manuscript online: 5 MAR 2012 12:21AM EST
- Manuscript Accepted: 28 FEB 2012
- Manuscript Revised: 24 FEB 2012
- Manuscript Received: 20 JAN 2012
- American Academy of Neurology
- Northeast Ohio Medical University
- NEOMED Research Incentive Award
- dopamine transporter;
- Parkinson's disease
A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg kg−1), at 30 min prior to injection of methamphetamine (40 mg kg−1) significantly decreased the amount of striatal dopamine depletion in male, but not female, mice, thereby abolishing the sex difference in methamphetamine-induced neurotoxicity (males > females). In Experiment 2, the methamphetamine-evoked sex differences in dopamine and DOPAC output from superfused striatal tissue (males > females) were abolished in mice treated with nomifensine at 30 min prior to tissue removal. In Experiment 3, the potassium chloride-evoked sex differences in dopamine and DOPAC output from superfused striatal tissue (females > males) were reversed in mice treated with nomifensine at 30 min prior to tissue removal. Taken together these results demonstrate the critical role played by catecholamine transporters in sex differences of dopaminergic function and suggest that this may involve the dopamine transporter, due to its high concentrations within the striatum. Such findings highlight the need for gender-specific considerations in use of treatments that target reuptake transporters function. Synapse, 2012. © 2012 Wiley Periodicals, Inc.