Mice lacking neuropeptide Y show increased sensitivity to cocaine

Authors

  • Gunnar Sørensen,

    1. Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
    2. Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
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  • David P.D. Woldbye

    Corresponding author
    1. Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
    2. Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    • Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute, Building 24.2, 3 Blegdamsvej, DK-2200 Copenhagen, Denmark
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Abstract

There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined. Synapse 66:840–843, 2012. © 2012 Wiley Periodicals, Inc.

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