The selective D3 receptor antagonist SB-277011A attenuates morphine-triggered reactivation of expression of cocaine-induced conditioned place preference
Article first published online: 25 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 67, Issue 8, pages 469–475, August 2013
How to Cite
Rice, O. V., Heidbreder, C. A., Gardner, E. L., Schonhar, C. D. and Ashby, C. R. (2013), The selective D3 receptor antagonist SB-277011A attenuates morphine-triggered reactivation of expression of cocaine-induced conditioned place preference. Synapse, 67: 469–475. doi: 10.1002/syn.21653
- Issue published online: 22 JUN 2013
- Article first published online: 25 MAR 2013
- Accepted manuscript online: 13 FEB 2013 04:43AM EST
- Manuscript Accepted: 11 FEB 2013
- Manuscript Revised: 8 FEB 2013
- Manuscript Received: 23 AUG 2012
- National Institute of General Medical Sciences (NIGMS). Grant Number: P20GM103499
- D3 receptor;
- conditioned place preference
We examined the effect of acute administration of the selective D3 receptor antagonist SB-277011A on morphine-triggered reactivation of cocaine-induced conditioned place preference (CPP) in adult male Sprague-Dawley rats. Repeated pairing of animals with 15 mg/kg i.p. of cocaine HCl or vehicle to cue-specific CPP chambers produced a significant CPP response compared to animals paired only with vehicle in both chambers. Expression of the CPP response to cocaine was then extinguished by repeatedly giving the animals vehicle injections in the cocaine-paired chambers. The magnitude of the CPP response after extinction was not significantly different from that of animals paired only with vehicle. Expression of the extinguished CPP response was reactivated by acute administration of 5 mg/kg i.p. of morphine but not by vehicle. Acute administration of 6 or 12 mg/kg i.p. (but not 3 mg/kg) of SB-277011A significantly attenuated morphine-triggered reactivation of the cocaine-induced CPP. SB-277011A itself (12 mg/kg i.p.) did not reactivate the extinguished CPP response. Overall, SB-277011A decreases the incentive motivational actions of morphine. The present findings suggest that central D3 dopamine receptors are involved in relapse to cocaine-seeking behavior, that a final common neural mechanism exists to mediate the incentive motivational effects of psychostimulants and opiates, and that selective dopamine D3 receptor antagonists constitute promising compounds for treating addiction. Synapse 67:469–475, 2013. © 2013 Wiley Periodicals, Inc.