Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides
Article first published online: 23 JUL 2013
Copyright © 2013 Wiley Periodicals, Inc.
Volume 68, Issue 3, pages 127–130, March 2014
How to Cite
Bach, H., Huang, Y.-Y., Underwood, M. D., Dwork, A. J., Mann, J. J. and Arango, V. (2014), Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides. Synapse, 68: 127–130. doi: 10.1002/syn.21695
- Issue published online: 21 JAN 2014
- Article first published online: 23 JUL 2013
- Accepted manuscript online: 29 JUN 2013 07:02AM EST
- Manuscript Accepted: 14 JUN 2013
- Manuscript Revised: 6 JUN 2013
- Manuscript Received: 17 APR 2013
- NIMH. Grant Numbers: MH40210, MH62185, MH64168
- prefrontal cortex
Using high pressure liquid chromatography, we find more brainstem 5-HT and 5-HIAA in suicides compared with nonpsychiatric, sudden death controls throughout the rostrocaudal extent of the brainstem DRN and MRN. This suggests that 5-HT synthesis in suicides is greater within all DRN subnuclei and the MRN compared with controls.