Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides

Authors

  • Helene Bach,

    Corresponding author
    1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
    2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
    • Correspondence to: Helene Bach, PhD, Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA. E-mail: hb2104@columbia.edu

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  • Yung-Yu Huang,

    1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
    2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
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  • Mark D. Underwood,

    1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
    2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
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  • Andrew J. Dwork,

    1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
    2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
    3. Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York
    4. Macedonian Academy of Sciences and Arts, Republic of Macedonia
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  • J. John Mann,

    1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
    2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
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  • Victoria Arango

    1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
    2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
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Abstract

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Using high pressure liquid chromatography, we find more brainstem 5-HT and 5-HIAA in suicides compared with nonpsychiatric, sudden death controls throughout the rostrocaudal extent of the brainstem DRN and MRN. This suggests that 5-HT synthesis in suicides is greater within all DRN subnuclei and the MRN compared with controls.

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