Electrophysiological actions of luteinizing hormone-realeasing hormone: Intracellular studies in the rat hippocampal slice preparation
Article first published online: 12 OCT 2004
Copyright © 1990 Wiley-Liss, Inc.
Volume 5, Issue 1, pages 65–70, 1990
How to Cite
Wong, M., Eaton, M. J. and Moss, R. L. (1990), Electrophysiological actions of luteinizing hormone-realeasing hormone: Intracellular studies in the rat hippocampal slice preparation. Synapse, 5: 65–70. doi: 10.1002/syn.890050106
- Issue published online: 12 OCT 2004
- Article first published online: 12 OCT 2004
- Manuscript Accepted: 21 SEP 1989
- Manuscript Received: 14 AUG 1989
- Ca1 neurons;
The electrophysilogical effects of luteinizing hormone-releasing hormone (LHRH) on CA1 pyramidal cells were investigated utilizing intracellular recodings from the in vitro rat hippocampal slce preparation. Bath application of LHRH (10-7-10-12M) resulted in several changes in the electrophysiological properties of CA1 neurons. LHRH induced a long-lasting depolarization associated with increased input resitance, and decrease in the afterhyperpolarization associated with increased input resistance, ad decrease in the afterhyperpolarization (AHP) following a train of action potentials, and a reduction in accommodation of repetitive cell discharge. These effects were blocked by the synthetic LHRH antagonist [Ac-δ-Pro1, pCl-D-Phe2, D-Trp3,6]-LHRH. These findings provide electrophysiological evidence for the role of LHRH as a neurotransmitter/neuromodulator in the hippocampus.