Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims
Article first published online: 12 OCT 2004
Copyright © 1992 Wiley-Liss, Inc.
Volume 10, Issue 1, pages 79–82, January 1992
How to Cite
Biegon, A. and Fieldust, S. (1992), Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims. Synapse, 10: 79–82. doi: 10.1002/syn.890100111
- Issue published online: 12 OCT 2004
- Article first published online: 12 OCT 2004
- Manuscript Accepted: 29 SEP 1991
- Manuscript Received: 19 SEP 1991
- Norepinephrine (noradrenaline);
- Human brain;
Antibodies against tyrosine hydroxylase (TH, the rate-limiting enzyme in norepinephrine synthesis) and dopamine β-hydroxylase (DBH, the last enzyme in the synthesis) were used for immunohistochemical staining of human brain locus coeruleus sections, obtained postmortem form suicide victims and matched controls. Stain density over individual cells was quantified by a computerized, video-camera-based image analysis system. Mean stain density for TH was significantly lower (by about 30%) in the locus coeruleus of suicide victims. There was no difference between suicides and controls in DBH immunoreactivity or in the number of TH immunoreactive cells. Reduced TH availability, either genetically or environmentally determined, may contribute to the noradrenergic insufficiency postulated to occur in depression and the increased β-adrenergic receptor concentrations observed in prefrontal cortex of suicide victims.