Effects of high-dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography
Article first published online: 12 OCT 2004
Copyright © 1992 Wiley-Liss, Inc.
Volume 11, Issue 4, pages 287–293, August 1992
How to Cite
Brunswick, D. J., Benmansour, S., Tejani-Butt, S. M. and Hauptmann, M. (1992), Effects of high-dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Synapse, 11: 287–293. doi: 10.1002/syn.890110404
- Issue published online: 12 OCT 2004
- Article first published online: 12 OCT 2004
- Manuscript Accepted: 12 DEC 1991
- Manuscript Received: 7 MAR 1991
The neurotoxicity of methamphetamine to monoaminergic neurons was examined. Neurotoxicity was assessed by quantitative autoradiography using radioligands specific for binding to norepinephrine, dopamine, and serotonin uptake sites. High-dose administration of methamphetamine led to decreases in binding to uptake sites for the three monoamines. Norepinephrine binding sites were decreased in certain amygdaloid nuclei and in the dorsomedial hypothalamic nucleus. Serotonin binding sites were reduced in widespread brain areas, while dopamine binding sites were reduced in the caudate putamen, olfactory tubercle, and nucleus accumbens. The decreases in binding site density for the three monoamines are limited to terminal field areas; cell body areas are not affected. Our results indicate that methamphetamine is neurotoxic to serotonin, dopamine, and norepinephrine neurons. The neurotoxicity to norepinephrine neurons is in selected brain areas. © Wiley-Liss, Inc.