P.O. Fernagut, W.G. Meissner, M. Biran, M. Fantin, F. Bassil, J.M. Franconi and F. Tison
This work demonstrates that a genetic mouse model of multiple system atrophy recapitulates some of the progressive features of the disease, including age-related behavioural impairments and brain atrophy, together with a high burden of alpha-synuclein accumulation in the basal ganglia. This study delivers endpoints for the evaluation of therapeutic strategies.