Cover image for Vol. 68 Issue 4

April 2014

Volume 68, Issue 4

Pages spcone–spcone, 131–177

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Research Articles
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      Issue Information (page spcone)

      Article first published online: 12 FEB 2014 | DOI: 10.1002/syn.21706

  2. Research Articles

    1. Top of page
    2. Issue Information
    3. Research Articles
    1. Anatomical and pharmacological characterization of catecholamine transients in the medial prefrontal cortex evoked by ventral tegmental area stimulation (pages 131–143)

      Tatiana A. Shnitko and Donita L. Robinson

      Article first published online: 28 NOV 2013 | DOI: 10.1002/syn.21723

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      Voltammetric measurements of catecholamines in the medial prefrontal cortex are infrequent because of lack of chemical selectivity between dopamine and norepinephrine and overlapping anatomical input. Here, we validated electrical stimulation of the ventral tegmental area (VTA) as a method to evoke dopamine rather than norepinephrine release in the mPFC.

    2. Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P (pages 144–152)

      Jin Xu, Mingming Xu, Elizabeth Bolan, Annie-Kim Gilbert, Gavril W. Pasternak and Ying-Xian Pan

      Article first published online: 16 JAN 2014 | DOI: 10.1002/syn.21727

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      Three splice variants from the mouse Oprm1 gene were isolated and characterized. All encode full length, seven transmembrane domain receptors with high affinity for mu opioid drugs. Despite similar binding affinities for mu opioids, the variants differed in their transduction properties, as determined by activation of 35S-GTPγS binding, consistent with biased signaling.

    3. Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state (pages 153–158)

      Masahiko Odo, Keito Koh, Tomohiko Takada, Akira Yamashita, Michiko Narita, Naoko Kuzumaki, Daigo Ikegami, Hiroyasu Sakai, Masako Iseki, Eiichi Inada and Minoru Narita

      Article first published online: 16 JAN 2014 | DOI: 10.1002/syn.21728

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      The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve-ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness, was significantly greater than those in sham-operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve-ligated mice were significantly lower than those in sham-operated mice.

    4. Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats (pages 159–167)

      Lucia A. Ruocco, Emilia Romano, Concetta Treno, Enza lacivita, Arra Claudio, Ugo A. Gironi-Carnevale, Domenica Travaglini, Marcello Leopoldo, Giovanni Laviola, Adolfo G. Sadile and Walter Adriani

      Article first published online: 2 DEC 2013 | DOI: 10.1002/syn.21724

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      Subchronic stimulation of 5-HT7-Rs during the prepuberal period (PND 31-44, by LP-211 at 0.5 mg/kg/day) increases EZM head-dips (i.e. riskseeking propensity) in adolescent NHE rats. Thus, increased ongoing dysinhibition was produced in a model for hyperactivity and impaired attention.

    5. Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model (pages 168–177)

      Ao Zhan, Xin Xu, Ling Chen, Xuefeng Wang, Xie Yanfeng, Wei Dan, Yan Zhan and Quanhong Shi

      Article first published online: 20 DEC 2013 | DOI: 10.1002/syn.21725

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      In animal studies, the authors show that Gab2 expression was decreased at different time points after kindling compared to the controls and the lowest level of Gab2 expression occurred at 1 week. This finding of Gab2 suggests that it may play an important role in the pathogenesis of TLE.