Neonatal exposure to MK-801 reduces mRNA expression of mGlu3 receptors in the medial prefrontal cortex of adolescent rats (pages 202–208)
Takashi Uehara, Tomiki Sumiyoshi, Dan Rujescu, Just Genius, Tadasu Matsuoka, Ichiro Takasaki, Hiroko Itoh and Masayoshi Kurachi
Article first published online: 19 FEB 2014 | DOI: 10.1002/syn.21734
This study demonstrates that NMDA-R dysfunction, resulting from transient neonatal treatment with MK-801, an NMDA-R antagonist, leads to downregulation of mGluR3 mRNA in the medial prefrontal cortex (mPFC) around puberty, particularly at postnatal day 35 (preadolescence). As the pathophysiology of schizophrenia is thought to include the hypofunction of NMDA-R and subsequent pathways, this finding implicates mGluR3 as a potential target candidate for preventing the onset and progression of this disorder.