Cover image for Vol. 68 Issue 5

May 2014

Volume 68, Issue 5

Pages spcone–spcone, 179–233

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Research Articles
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      Issue Information (page spcone)

      Version of Record online: 13 MAR 2014 | DOI: 10.1002/syn.21707

  2. Research Articles

    1. Top of page
    2. Issue Information
    3. Research Articles
    1. Correlation between the effects of local and intracerebroventricular infusions of galanin on 5-HT release studied by microdialysis, and distribution of galanin and galanin receptors in prefrontal cortex, ventral hippocampus, amygdala, hypothalamus, and striatum of awake rats (pages 179–193)

      Shimako Yoshitake, Eugenia Kuteeva, Tomas Hökfelt, Françoise Mennicken, Elvar Theodorsson, Masatoshi Yamaguchi, Jan Kehr and Takashi Yoshitake

      Version of Record online: 3 FEB 2014 | DOI: 10.1002/syn.21730

      Thumbnail image of graphical abstract

      Differential effects of intracerebroventricular (i.c.v.) and intracerebral (local) infusions of galanin on basal extracellular 5-HT levels in five selected regions of adult rat brain. Galanin-induced effects on 5-HT release correlated with strong to moderate density of galanin positive terminals in mPFC, vHPC, and CeA. Correspondingly, the lack of effect on 5-HT release correlated with moderate to low galanin fibre densities in VMHvl and CPu.

    2. Distribution of AMPA receptor subunit glur1 in the bed nucleus of the stria terminalis and effect of stress (pages 194–201)

      George W. Hubert and E. Chris Muly

      Version of Record online: 3 FEB 2014 | DOI: 10.1002/syn.21729

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      Previously, we found that stress shifts the AMPA receptor subunit GluR1 into dendritic spines and suggested this might result in un-silencing excitatory inputs to this brain region. Here, we find a similar shift does not occur in the BNST, a major target of the BLA.

    3. Neonatal exposure to MK-801 reduces mRNA expression of mGlu3 receptors in the medial prefrontal cortex of adolescent rats (pages 202–208)

      Takashi Uehara, Tomiki Sumiyoshi, Dan Rujescu, Just Genius, Tadasu Matsuoka, Ichiro Takasaki, Hiroko Itoh and Masayoshi Kurachi

      Version of Record online: 19 FEB 2014 | DOI: 10.1002/syn.21734

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      This study demonstrates that NMDA-R dysfunction, resulting from transient neonatal treatment with MK-801, an NMDA-R antagonist, leads to downregulation of mGluR3 mRNA in the medial prefrontal cortex (mPFC) around puberty, particularly at postnatal day 35 (preadolescence). As the pathophysiology of schizophrenia is thought to include the hypofunction of NMDA-R and subsequent pathways, this finding implicates mGluR3 as a potential target candidate for preventing the onset and progression of this disorder.

    4. Effects of antidepressant drug exposure on gene expression in the developing cerebral cortex (pages 209–220)

      Evangelia M. Tsapakis, Cathy Fernandes, Taylor Moran-Gates, Amlan Basu, Karen Sugden, Katherine J. Aitchison and Frank I. Tarazi

      Version of Record online: 13 FEB 2014 | DOI: 10.1002/syn.21732

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      Gene expression in developing rat cortex was evaluated using microarray chip after 3-weeks of treatment with the antidepressants fluoxetine and imipramine. Both drugs increased expression of four genes and decreased expression of six genes involved in cell signalling, survival and protein metabolism. These findings suggest that antidepressant drugs target highly specific transcriptional programs in the developing brain.

    5. Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective dopaminergic drugs and methamphetamine (pages 221–233)

      Kiera-Nicole Lee, Samuel T. Pellom, Ericka Oliver and Sanika Chirwa

      Version of Record online: 31 JAN 2014 | DOI: 10.1002/syn.21731

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      The authors have characterized guinea pigs spontaneous and drug-induced behaviors across circadian cycles. Animals were very active and lacked distinct long periods indicative of sleep. Selective dopaminergic agonist or antagonists did not alter activity profiles. Acute high-dose methamphetamine produced hyperactivity and increased total distance travelled. Chronic methamphetamine produced motor sensitization.