Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain (pages 235–247)
Akira Yamashita, Asami Hamada, Yuki Suhara, Rui Kawabe, Makoto Yanase, Naoko Kuzumaki, Michiko Narita, Ryosuke Matsui, Hideyuki Okano and Minoru Narita
Article first published online: 24 FEB 2014 | DOI: 10.1002/syn.21733
Neuropathic pain-like stimuli can accelerate the ascending pain pathway and eventually induce over-activity of the astrocytes and the suppression of GABA transmission in the anterior cingulate cortex, which may promote sleep disturbance under pain. Activated astrocytes may, at least in part, induce insomnia in patients with neuropathic pain.