Synapse

Cover image for Vol. 68 Issue 6

June 2014

Volume 68, Issue 6

Pages spcone–spcone, 235–282

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Research Articles
    1. You have free access to this content
      Issue Information (page spcone)

      Article first published online: 4 APR 2014 | DOI: 10.1002/syn.21708

  2. Research Articles

    1. Top of page
    2. Issue Information
    3. Research Articles
    1. Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain (pages 235–247)

      Akira Yamashita, Asami Hamada, Yuki Suhara, Rui Kawabe, Makoto Yanase, Naoko Kuzumaki, Michiko Narita, Ryosuke Matsui, Hideyuki Okano and Minoru Narita

      Article first published online: 24 FEB 2014 | DOI: 10.1002/syn.21733

      Thumbnail image of graphical abstract

      Neuropathic pain-like stimuli can accelerate the ascending pain pathway and eventually induce over-activity of the astrocytes and the suppression of GABA transmission in the anterior cingulate cortex, which may promote sleep disturbance under pain. Activated astrocytes may, at least in part, induce insomnia in patients with neuropathic pain.

    2. Chronic administration of nicotine enhances NMDA-activated currents in the prefrontal cortex and core part of the nucleus accumbens of rats (pages 248–256)

      Tania Ávila-Ruiz, Vladimir Carranza, López-López Gustavo, Daniel I. Limón, Isabel Martínez, Gonzalo Flores and Jorge Flores-Hernández

      Article first published online: 18 FEB 2014 | DOI: 10.1002/syn.21726

      Thumbnail image of graphical abstract

      Nicotine treatment for 14 days induces an increase in NMDA current amplitude that is related to an increase in the number of receptors rather than a possible change in subunit expression.

    3. Phencyclidine rapidly decreases neuronal mRNA of brain-derived neurotrophic factor (pages 257–265)

      Yusuke Katanuma, Tadahiro Numakawa, Naoki Adachi, Noriko Yamamoto, Yoshiko Ooshima, Haruki Odaka, Takafumi Inoue and Hiroshi Kunugi

      Article first published online: 24 FEB 2014 | DOI: 10.1002/syn.21735

      Thumbnail image of graphical abstract

      The authors show that phencyclidine (PCP), a noncompetitive NMDA receptor blocker, rapidly decreased BDNF mRNA in cultured cortical neurons. PCP mainly reduced transcripts derived from BDNF exon IV through inhibiting CaMKII/CREB signaling.

    4. Cortical dopamine release during a behavioral response inhibition task (pages 266–274)

      Daniel S. Albrecht, David A. Kareken, Bradley T. Christian, Mario Dzemidzic and Karmen K. Yoder

      Article first published online: 28 FEB 2014 | DOI: 10.1002/syn.21736

      Thumbnail image of graphical abstract

      This proof-of-principle study sought to determine whether a stop-signal task could induce detectable changes in cortical dopamine. Using [18F]fallypride PET, we found that the stop-signal task elicited significant changes in dopamine in several cortical regions implicated in inhibitory control.

    5. Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy (pages 275–282)

      Wei Liu, Rui Shi, Wenxiu Yang, Nan Zhao, Yingshi Du, Yan Zou and Weihua Yu

      Article first published online: 11 MAR 2014 | DOI: 10.1002/syn.21739

      Thumbnail image of graphical abstract

      Transforming growth factor β (TGFβ) signaling participates in the epileptogenesis. STRAP and Smad7 synergize in the inhibition of TGFβ signaling. Results indicate that STRAP level was significantly decreased in 24 h, 72 h (acute stage), 1 week (latent stage), 1 month, 2 months (chronic stage), respectively, in the rats model compared with the normal rats by using both western blotting and immunohistochemistry in the hippocampus and temporal lobe cortex of pilocarpine-induced epilepsy rats. Smad7 had similar reduced pattern as STRAP. We concluded that STRAP and Smad7 proteins might be involved in the development of temporal lobe epilepsy.

SEARCH

SEARCH BY CITATION