Synapse

Cover image for Vol. 68 Issue 7

July 2014

Volume 68, Issue 7

Pages spcone–spcone, 283–323

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Research Articles
    4. Short Communication
    1. You have free access to this content
      Issue Information (page spcone)

      Article first published online: 12 MAY 2014 | DOI: 10.1002/syn.21709

  2. Research Articles

    1. Top of page
    2. Issue Information
    3. Research Articles
    4. Short Communication
    1. Development of novel PET probe [11C](R,R)HAPT and its stereoisomer [11C](S,S)HAPT for vesicular acetylcholine transporter imaging: A PET study in conscious monkey (pages 283–292)

      Shingo Nishiyama, Hiroyuki Ohba, Tatsuhiro Kobashi, Yumi Nakamasu, Hidekazu Nakao, Tokutaro Ogata, Takeru Kitashoji and Hideo Tsukada

      Article first published online: 12 APR 2014 | DOI: 10.1002/syn.21743

      Thumbnail image of graphical abstract

      [11C](R,R)HAPT and its stereoisomer [11C](S,S)HAPT were developed for imaging vesicular acetylcholine transporters (VAChT), located in presynaptic cholinergic neurons in the brain. [11C](R,R)HAPT binding in the monkey brain was displaced by vesamicol, a specific VAChT antagonist, but not by SA4503, a sigma-1 agonist, suggesting the specificity of [11C](R,R)HAPT to VAChT.

    2. You have free access to this content
      Environmental enrichment alters structural plasticity of the adolescent brain but does not remediate the effects of prenatal nicotine exposure (pages 293–305)

      Richelle Mychasiuk, Arif Muhammad and Bryan Kolb

      Article first published online: 4 MAR 2014 | DOI: 10.1002/syn.21737

      Thumbnail image of graphical abstract

      Using Golgi-Cox staining and analysis of the rodent medial prefrontal cortex, orbital frontal cortex, and nucleus accumbens, the authors have demonstrated that a majority of the alterations to neuronal morphology associated with prenatal nicotine exposure are not reversed by environmental enrichment in adolescence.

    3. Altered expression of c-Abl in patients with epilepsy and in a rat model (pages 306–316)

      Ling Chen, Zhihua Wang, Bo Tang, Min Fang, Jie Li, Guojun Chen and Xuefeng Wang

      Article first published online: 2 APR 2014 | DOI: 10.1002/syn.21741

      Thumbnail image of graphical abstract

      Using double immunolabeling, immunohistochemistry, and immunoblotting, we found that c-Abl was expressed in the membrane and cytoplasm of neurons and both total and phosphorylated c-Abl was upregulated in patients with TLE. In experimental rats, c-Abl levels increased from 6 h to 60 days postseizures. These data implicate that c-Abl may play a role in the development of TLE.

  3. Short Communication

    1. Top of page
    2. Issue Information
    3. Research Articles
    4. Short Communication
    1. Changes in dopamine release and dopamine D2/3 receptor levels with the development of mild obesity (pages 317–320)

      Robert M. Kessler, David H. Zald, Mohammad Sib Ansari, Rui Li and Ronald L. Cowan

      Article first published online: 17 MAR 2014 | DOI: 10.1002/syn.21738

      Thumbnail image of graphical abstract

      [18F]Fallypride PET studies were used to estimate regional DA D2/3 receptor levels and DA release in healthy subjects with BMI's from 19 to 35. Significant, positive correlations of BMI with DA release were seen; correlations with DA D2/3 levels were negative and of borderline significance.

    2. Olfactory tubercle neurons exhibit slow-phasic firing patterns during cocaine self-administration (pages 321–323)

      Brendan M. Striano, David J. Barker, Anthony P. Pawlak, David H. Root, Anthony T. Fabbricatore, Kevin R. Coffey, Joshua P. Stamos and Mark O. West

      Article first published online: 15 APR 2014 | DOI: 10.1002/syn.21744

      Thumbnail image of graphical abstract

      Electrophysiological recordings from the Olfactory Tubercle (OT) of rats trained to self-administer cocaine were analyzed for distinct firing patterns. Observation revealed that neurons demonstrated changes in firing correlated with the calculated fluctuating levels of cocaine. These are the first electrophysiological data suggesting a role for the OT in drug self-administration.

SEARCH

SEARCH BY CITATION