The Chemical Record

Cover image for Vol. 12 Issue 4

Special Issue: Topical Cluster: Nagoya Gold Medal Series

August 2012

Volume 12, Issue 4

Pages 371–455

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Reviews
    7. Record and Challenge
    1. You have free access to this content
      Cover Picture (page 371)

      Article first published online: 22 AUG 2012 | DOI: 10.1002/tcr.201290009

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  2. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Reviews
    7. Record and Challenge
    1. Masthead (page 372)

      Article first published online: 22 AUG 2012 | DOI: 10.1002/tcr.201290010

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Reviews
    7. Record and Challenge
    1. Graphical Abstract: Chem. 4/2012 (pages 373–374)

      Article first published online: 22 AUG 2012 | DOI: 10.1002/tcr.201290011

  4. Editorial

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Reviews
    7. Record and Challenge
    1. You have free access to this content
      The Nagoya Gold Medal Series (page 375)

      Ryoji Noyori

      Article first published online: 22 AUG 2012 | DOI: 10.1002/tcr.201210001

  5. Reviews

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Reviews
    7. Record and Challenge
    1. On Being Green: Can Flow Chemistry Help? (pages 378–390)

      Steven V. Ley

      Article first published online: 18 JUN 2012 | DOI: 10.1002/tcr.201100041

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      The principles of Green Chemistry are important but challenging drivers for most modern synthesis programs. To meet these challenges new flow chemistry tools are proving to be very effective by providing improved heat/mass transfer opportunities, lower solvent usage, less waste generation, hazardous compound containment, and the possibility of a 24/7 working regime. This machine-assisted approach can be used to effect repetitive or routine scale-up steps or when combined with reagent and scavenger cartridges, to achieve multi-step synthesis of complex natural products and pharmaceutical agents.

    2. Artificial Metalloenzymes as Catalysts in Stereoselective Diels–Alder Reactions (pages 391–406)

      Manfred T. Reetz

      Article first published online: 18 JUN 2012 | DOI: 10.1002/tcr.201100043

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      Anchoring transition metals in appropriate protein hosts lead to the creation of hybrid catalysts which act as artificial metalloenzymes for asymmetric Diels–Alder reactions.

    3. A Total Synthesis Trilogy: Calicheamicin γ1I, Taxol®, and Brevetoxin A (pages 407–441)

      K. C. Nicolaou, Christopher R. H. Hale and Christian Nilewski

      Article first published online: 18 JUN 2012 | DOI: 10.1002/tcr.201200005

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      How calicheamicin γ1I, Taxol®, and brevetoxin A were made in the lab: The total syntheses of these complex biologically active natural products are described with great detail in this article, with special emphasis on synthetic strategy and design, and redesign in order to overcome pitfalls and dead ends.

  6. Record and Challenge

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Reviews
    7. Record and Challenge

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