The study was designed to determine differences between two chemistry teaching methods on students' chemistry achievement and attitudes toward science. The two methods were the large lecture-demonstration and small-group laboratory approaches to teaching chemistry. The subjects were 74 eleventh-grade Saudi Arabian students randomly assigned to the two treatment groups. The findings revealed that the small-group laboratory students exhibited significantly greater chemistry achievement than students in the lecture-demonstration group on both immediate and delayed posttests. The results also indicated that students taught by the lab approach possessed more desirable attitudes toward science.