Publication 417 from the McGill University-Montreal Children's Hospital Research Institute. Supported by a Medical Research Council Genetics Group grant.
Genetics and Cytogenetics
Inheritance of branchial sinuses and preauricular fistulae†
Article first published online: 10 MAY 2005
Copyright © 1974 Wiley-Liss, Inc., A Wiley Company
Volume 9, Issue 2, pages 225–228, April 1974
How to Cite
Hunter, A. G. W. (1974), Inheritance of branchial sinuses and preauricular fistulae. Teratology, 9: 225–228. doi: 10.1002/tera.1420090214
- Issue published online: 10 MAY 2005
- Article first published online: 10 MAY 2005
- Manuscript Accepted: 23 OCT 1973
- Manuscript Received: 28 JUL 1973
On the basis of two families in which branchial sinus and pre-auricular fistulas occurred together, and a review of the literature, it is proposed that the two conditions can result from an autosomal dominant gene with some-what reduced penetrance and variable expressivity. Embryo logical considerations suggest that the mutant gene may interfere with proper obliteration of the pharyngeal clefts, whichmay lead to either or both of the two lesions. Conductive deafness may also occur as part of the syndrome.