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The fetal alcohol syndrome

Authors

  • Kenneth L. Jones,

    1. Dysmorphology Unit, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, and Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California 92103
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  • Dr. David W. Smith

    Corresponding author
    1. Dysmorphology Unit, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, and Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California 92103
    • Department of Pediatrics, RR234 Health Sciences, RD-20, University of Washington School of Medicine, Seattle, Washington 98195
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  • Supported by the Maternal and Child Health Services, Health Services and Mental Administration, Department of Health, Education and Welfare Project 913, NIH grants HD05961 and GM15253, and the National Foundation — March of Dimes.

  • Presented as a Special Lecture at the 14th Annual Meeting of the Teratology Society, July 7–10, 1974, University of British Columbia, Vancouver, B. C., Canada.

Abstract

A specific pattern of malformation involving prenatal-onset growth deficiency, developmental delay, craniofacial anomalies, and limb defects is now recognized in offspring of chronic alcoholic women, Historical evidence suggests that this is not a new observation. A recent French study of 127 offspring of alcoholic mothers indicates that this specific syndrome has been recognized in other parts of the world. Many of the features of this disorder could be related to the kind of malorientation of brain structure seen at the autopsy of one patient described herein. The frequency (43%) of adverse outcome of pregnancy for chronic alcoholic women suggests that serious consideration be given to early termination of pregnancy in severely chronic alcoholic women.

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