Differences in frequency of cleft lip among the a strains of mice


  • D. M. Juriloff

    Corresponding author
    1. The Jackson Laboratory, Bar Harbor, Maine 04609
    • Department of Medical Genetics, The University of British Columbia, #235 -5804 Fairview Crescent, Vancouver, B.C., Canada V6T 1W5
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The frequency of spontaneous cleft lip on Day 14 of gestation was examined in the A/J, A/HeJ, A/WySn, A.BY/Sn, A.SW/Sn, Bl0.A/SgSn, and B10.A(2R)/SgSn inbred strains of mice. A/WySn was found to have a higher frequency of cleft lip (20–30%) than A/J or A/HeJ (10%). Differences among strains in laterality of clefting and in rates of differential mortality of affected embryos were also found. Results of crosses between A/WySn and A/HeJ suggested that the difference in rate of clefting may be due to a genetic maternal effect. The results for A.BY/Sn, A.SW/Sn, Bl0.A/SgSn and B10.A(2R)/SgSn indicated that no association of cleft lip liability and the H-2 complex was detectable.