The teratogenicity of cocaine

Authors

  • Dr. Alan G. Fantel,

    1. Department of Pediatrics, University of Washington, School of Medicine, Seattle, Washington 98195
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    • Dr. Fantel is an Affiliate of the Child Development and Mental Retardation Center.

  • Bonita J. MacPhail

    1. Department of Pediatrics, University of Washington, School of Medicine, Seattle, Washington 98195
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Abstract

Pregnant rats and mice received high doses of cocaine hydrochloride by intraperitoneal injection. Despite treatment periods which included most of organogenesis, no increase in congenital abnormalities was observed. Rats showed significant reductions in maternal and fetal weights as well as increased resorption frequencies. Fetal edema was also found. Mice showed only decreased fetal weights with no increase in malformations.

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