Dr. Fantel is an Affiliate of the Child Development and Mental Retardation Center.
Developmental Pharmacology and Toxicology
The teratogenicity of cocaine
Article first published online: 19 MAY 2005
Copyright © 1982 Wiley-Liss, Inc., A Wiley Company
Volume 26, Issue 1, pages 17–19, August 1982
How to Cite
Fantel, A. G. and MacPhail, B. J. (1982), The teratogenicity of cocaine. Teratology, 26: 17–19. doi: 10.1002/tera.1420260104
- Issue published online: 19 MAY 2005
- Article first published online: 19 MAY 2005
- Manuscript Accepted: 11 MAR 1982
- Manuscript Received: 4 AUG 1980
Pregnant rats and mice received high doses of cocaine hydrochloride by intraperitoneal injection. Despite treatment periods which included most of organogenesis, no increase in congenital abnormalities was observed. Rats showed significant reductions in maternal and fetal weights as well as increased resorption frequencies. Fetal edema was also found. Mice showed only decreased fetal weights with no increase in malformations.