Thomas H. Shepard and Alan G. Fantel are affiliates of the Child Development and Mental Retardation Center.
Sodium salicylate teratogenicity in vitro
Article first published online: 19 MAY 2005
Copyright © 1982 Wiley-Liss, Inc., A Wiley Company
Volume 26, Issue 2, pages 167–171, October 1982
How to Cite
Greenaway, J. C., Shepard, T. H., Fantel, A. G. and Juchau, M. R. (1982), Sodium salicylate teratogenicity in vitro. Teratology, 26: 167–171. doi: 10.1002/tera.1420260209
- Issue published online: 19 MAY 2005
- Article first published online: 19 MAY 2005
- Manuscript Accepted: 10 OCT 1981
- Manuscript Received: 20 FEB 1981
Rat embryos were exposed to sodium salicylate in vitro at concentrations comparable to those used to produce terata in vivo. Embryos treated with 400, 600, or 800 μg Na salicylate/ml were compared with embryos treated with an equimolar concentration of NaCl. When compared to growth of the controls, a significant dose-dependent decrease in growth parameters was observed. The incidence of abnormal embryos characterized by generalized swelling (particularly in the area of the rhombencephalon) was also dose dependent. This study demonstrates the teratogenicity of salicylate in the rat independent of maternal factors.